: Michael J. Pharham, J. Bruinvels, Steven G. Elliott, Mary Ann Foote, Graham Molineux
: Steven G. Elliott, MaryAnn Foote, Graham Molineux
: Erythropoietins, Erythropoietic Factors, and Erythropoiesis Molecular, Cellular, Preclinical, and Clinical Biology
: Birkhäuser Basel
: 9783764386986
: 2
: CHF 190.00
:
: Pharmazie
: English
: 330
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators.

 

Contents6
List of contributors8
Preface to the first edition10
Preface to the second edition13
Abbreviations14
Background18
Erythropoiesis: an overview19
Normal erythropoiesis19
Erythropoietin23
Abnormal erythropoiesis27
A bright horizon or dark clouds?28
References30
Regulation of endogenous erythropoietin production35
Hypoxic regulation of erythropoietin35
Renal oxygenation and erythropoietin36
cis-acting regulatory elements of the erythropoietin gene37
EPO – a paradigm for widespread hypoxic gene regulation40
Hypoxia inducible-factor (H