: Michael J. Parnham, J. Bruinvels, Carlos A. Zarate, Husseini K Manji
: Carlos A. Zarate Jr., Husseini K. Manji
: Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy
: Birkhäuser Basel
: 9783764385675
: 1
: CHF 197.90
:
: Pharmazie
: English
: 286
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression.

Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments.

This volume offers researchers and clinicians key insights into this devastating disorder.

Contents6
List of contributors8
Acknowledgements10
Foreword11
Section A: Bipolar depression: Clinical phenotype and course of illness13
The history of bipolar disorders14
The clinical diagnosis of bipolar depression28
Course and outcome of bipolar disorder focusing on depressive aspects40
Suicide and bipolar disorder58
Section B: Bipolar depression: Neurobiology68
The genetic basis of bipolar disorder69
Understanding the neurobiology of bipolar depression87
Non-pharmacological treatments and chronobiological aspects of bipolar disorder: implications for novel therapeutics105
Neuroimaging studies of bipolar depression: therapeutic implications127
Section C: Acute and long-term treatment of bipolar disorder155
Pharmacological treatment of acute bipolar depression156
Pharmacological treatment of the maintenance phase of bipolar depression: focus on relapse prevention studies and the impact of design on generalizability168
Non-pharmacological somatic treatments for bipolar depression188
Potential novel treatments for bipolar depression200
Section D: Treatment of bipolar disorder in special populations219
Late-onset bipolar disorder220
Treatment of childhood-onset bipolar disorder247
Treatment of bipolar disorder during and after pregnancy259
Conclusion276
Index280
The MDT-Series Milestones in Drug Therapy285