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In Vivo Models of Inflammation Volume 1

:	Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan
:	Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan
:	In Vivo Models of Inflammation Volume 1
:	Birkhäuser Basel
:	9783764375201
:	2
:	CHF 133.60
:

:	Nichtklinische Fächer
:	English

:	211
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

In Vivo Models of Inflammation (Vol. 1) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first, describing and updating the standard models that are most utilized for specific disease areas. New models are included exploring emerging areas of inflammation research.

	Contents	5
	List of contributors	7
	Preface to the first edition	10
	Preface to the second edition	11
	Introduction	12
	Historical background	12
	Rat models of arthritis: Similarities, differences, advantages, and disadvantages in the identification of novel therapeutics	12
	Drug therapies	13
	Methods	27
	Conclusions	33
	References	36
	Introduction	46
	Murine collagen induced arthritis	46
	Induction of CIA	47
	Expression of arthritis	50
	Unilateral CIA	52
	CIA in C57BL/6 mice	53
	Passive transfer model of CIA	53
	Arthritis score and histopathology	54
	Cytokine involvement	58
	Applicability of the model	65
	Final remarks	69
	References	70
	Introduction	75
	Use of animal models of osteoarthritis in the evaluation of potential new therapeutic agents	75
	OA animal models	76
	Use of OA animal models in the evaluation of potential therapeutic modalities	76
	Conclusion	78
	References	86
	Introduction: Inflammation and cancer	93
	Models of inflammatory processes in cancer	93
	Inflammation as an initiator	94
	Inflammation as a promoter	94
	Inflammation as an immunosuppressor	94
	Models of the initiator/promotor activities of inflammation	95
	Models of angiogenesis	96
	In vivo tumor models	100
	Inflammation-related immune regulatory mechanisms	102
	Conclusions	104
	References	105
	Introduction	113
	Muscular dystrophy and the pathogenetic role of inflammation	113
	Advances in stem cell research: use of stem cells in animal models of muscular dystrophy	113
	Animal models of muscular dystrophy	116
	Inflammation in the dystrophic models	117
	Muscular dystrophy, regeneration and stem cells	119
	Enhancing stem cell mediated muscle regeneration	126
	Future prospects	126
	References	127
	Introduction	134
	Gene transfer technology	134
	Principles of gene transfer	135
	Non-viral methods for gene transfer	137
	Viral vectors for gene transfer	137
	Conclusion	143
	References	144
	Introduction	147
	Transgenics	147
	Background/literature summary	148
	Experimental descriptions	154
	Invasive and noninvasive methods to study inflammatory diseases	156
	Conclusions	158
	References	158
	Introduction	163
	Nanotechnology: Towards the detection and treatment of inflammatory diseases	163
	Nanotechnology for inflammation scientists	164
	Nanostructures and nanosystems	165
	Nanoparticles	169
	In vitro diagnostics	172
	Nanoarrays	173
	Application of nanosystems and nanoparticles in inflammation and cancer	173
	Summary and conclusions	178
	References	179
	Introduction	185
	UK legislation of in vivo aspects in inflammation research	185
	UK legislation	186
	The Certificate of Designation	188
	The Project Licence	188
	The Personal Licence	190
	Other legislative systems in the United States and Europe	191
	Opportunities for reduction, replacement and refinement in inflammation research	191
	Skills shortages in integrative inflammation research in the 21st century	192
	References	193
	Legal standing of the 3R principle	195
	Japanese guidelines and regulations for scientific and ethical animal experimentation	195
	Basic guidelines established by regulatory agencies	196
	Detailed guidelines formulated by the SCJ	197
	Deliberation on local self-regulation of animal experiments	198
	References	199
	Introduction	200
	United States guidelines and regulations in animal experimentation	200
	Federal laws	201
	Guide for the Care and Use of Laboratory Animals	204
	Food and Drug Administration, Good Laboratory Practices	205
	Specific considerations for animal models of inflammation	206
	Summary	208
	References	209
	Index	210