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Early Brain Injury or Cerebral Vasospasm Vol 2: Clinical Management

:	John H. Zhang, Ying Mao, Hua Feng
:	Hua Feng, Ying Mao, John H. Zhang
:	Early Brain Injury or Cerebral Vasospasm Vol 2: Clinical Management
:	Springer-Verlag
:	9783709103562
:	Acta Neurochirurgica Supplement
:	1
:	CHF 189.80
:

:	Klinische Fächer
:	English

:	255
:	Wasserzeichen
:	PC/MAC/eReader/Tablet
:	PDF

More than 40 articles provide an extensive coverage of clinical and basic science advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries. Early brain injury, the new frontier of subarachnoid research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hermorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.

	Chapter : The Role of Apolipoprotein E in the Pathological Events Following Subarachnoid Hemorrhage: A Review	15
	Introduction	15
	APOE and Outcome After SAH	15
	ApoE and Early Brain Injury After SAH	16
	ApoE and Cerebral Vasospasm After SAH	16
	Conclusion	16
	References	16
	Chapter : Mechanisms of Statin Treatment in Cerebral Vasospasm	18
	Introduction	18
	Materials and Methods	19
	Results	19
	Conclusion	20
	References	20
	Chapter : The Effect of Phosphodiesterase Inhibitor Tadalafil on Vasospasm Following Subarachnoid Hemorrhage in an Experimental	21
	Introduction	21
	Methods and Materials	22
	Animal Model	22
	Induction of Experimental SAH	22
	Perfusion-Fixation	22
	Embedding, Morphometry, and Statistical Analysis	22
	Results	22
	Discussion	23
	References	24
	Chapter : Effect of a Free Radical Scavenger, Edaravone, on Free Radical Reactions: Related Signal Transduction and Cerebral Va	25
	Introduction	25
	Materials and Methods	26
	Production of SAH	26
	Intravenous Injection of Edaravone	26
	Histological Evaluation	26
	Western Blotting	26
	Statistical Analysis	26
	Results	27
	Evaluation of Cerebral Vasospasm (Figs. 1 and 2)	27
	Expression of Rho-kinase (Fig. 3)	27
	Discussion	28
	Conclusion	29
	References	29
	Chapter : Comparison of Nimodipine Delivery Routes in Cerebral Vasospasm After Subarachnoid Hemorrhage: An Experimental Study i	31
	Introduction	31
	Materials and Methods	31
	Animal Groups	31
	Nimodipine Solution	32
	SAH Formation	32
	Angiography Procedure	32
	Perfusion-Fixation	32
	Neurological Parameters	32
	Embedding, Morphometry, and Statistical Analysis	33
	Results	33
	Pathological Measurements	33
	Mortality and Neurological Parameters	33
	Angiographic Measurements	34
	Discussion	35
	Conclusion	36
	References	36
	Chapter : Effect of Recombinant Osteopontin on Cerebral Vasospasm After Subarachnoid Hemorrhage in Rats	37
	Introduction	37
	Materials and Methods	37
	Experimental Model of SAH and Study Protocol	37
	Neurological Scoring	38
	India Ink angiography	38
	Severity of SAH	38
	Intracerebroventricular Infusion	38
	Statistics	39
	Results	39
	Conclusion	39
	References	40
	Chapter : The Effect of Intracisternal Zn (II) Protoporphyrin IX on Vasospasm Process in the Experimental Subarachnoid Hemorrha	41
	Introduction	41
	Methods and Materials	42
	Animal Model	42
	Induction of Experimental SAH	42
	Perfusion-Fixation	42
	Embedding, Morphometry, and Statistical Analysis	42
	Results	42
	Discussion	43
	References	44
	Chapter : Temporal Profile of the Effects of Intracisternal Injection of Magnesium Sulfate Solution on Vasodilation of Spastic	46
	Introduction	46
	Materials and Methods	47
	Results	47
	Temporal Profile of Changes in CSF Mg2+ and Ca2+ Concentrations	47
	Temporal Profile of Neuroimaging Changes	48
	Conclusion	48
	References	49
	Chapter : Comparison of Intrathecal Cilostazol and Nimodipine Treatments in Subarachnoid Hemorrhage: An Experimental Study in R	50
	Introduction	50
	Methods and Materials	51
	Induction of SAH	51
	Experimental Protocol	51
	Statistical Analysis	52
	Results	52
	Discussion	52
	Conclusion	54
	References	55
	Chapter : Blocking Cerebral Lymphatic Drainage Deteriorates Cerebral Oxidative Injury in Rats with Subarachnoid Hemorrhage	56
	Introduction	56
	Materials and Methods	56
	Animal Preparations	56
	Arterial Blood Gas and Blood Pressure Monitoring	57
	Serum Lactate Dehydrogenase Activity Detection	57
	Detection of Brain Tissue Superoxide Dismutase Activity and Malonaldehyde Content	57
	Statistical Analysis	57
	Results	58
	Behavior Observation and SAH Models Verification	58
	Arterial Blood Gas and Blood Pressure	58
	Serum Lactate Dehydrogenase Activity	58
	Brain Tissue Superoxide Dismutase Activity and Malonaldehyde Content	58
	Discussion	58
	References	59
	Chapter : Comparison of Intrathecal Dotariz