| Contents | 6 |
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| Contributors | 9 |
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| Science in the Context of Application: Methodological Change, Conceptual Transformation, Cultural Reorientation | 11 |
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| Research Going Practical: A Break with the Epistemic Past? | 11 |
| Changing Conditions of Scientific Research | 12 |
| Science, Values, and Society | 14 |
| Exploring Science in the Context of Application | 16 |
| References | 17 |
| Part I Changing Conditions of Scientific Research: Science and Technology | 18 |
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| Knowledge, Politics, and Commerce: Science Under the Pressure of Practice | 19 |
| Research in Extra-Scientific Interest | 19 |
| Problem Selection in Fundamental and Application-Driven Research | 21 |
| Three Ways of Selecting Research Topics | 24 |
| The Epistemic Dignity of Application-Oriented Research | 28 |
| Benefit and Hazard of Application-Oriented Research | 35 |
| References | 37 |
| Between the Pure and Applied: The Search for the Elusive Middle Ground | 39 |
| Introduction: Defining the Problem | 39 |
| Superconductivity: Puzzling Phenomenon to Microscopic Theory | 42 |
| From Materials Research to Josephson Junctions: Between Theory and Practice | 45 |
| From Theory to Machines and Back Again | 48 |
| Conclusions | 52 |
| References | 53 |
| Science in the Context of Industrial Application: The Case of the Philips Natuurkundig Laboratorium | 54 |
| Introduction | 54 |
| From Seamless Web to Ivory Tower | 56 |
| The Pains of ``Fundamental'' Ambitions | 59 |
| Finalization as a Feasible Alternative? | 64 |
| Mode-2 and Interdisciplinarity as New Ideals | 67 |
| Disentangling Dichotomies | 70 |
| References | 72 |
| Multi-Level Complexities in Technological Development: Competing Strategies for Drug Discovery | 74 |
| An Obstinate Dilemma in Early Drug Development | 74 |
| Rational Drug Design and Its Limits | 76 |
| High-Throughput Screening as Alternative and Complement to Rational Design | 80 |
| Systems Biology Challenges Mainstream Drug Discovery | 82 |
| Is Emergence the Problem? | 86 |
| References | 89 |
| Theory and Therapy: On the Conceptual Structure of Models in Medical Research | 91 |
| The Cascade Model: Control Presupposes Understanding | 91 |
| Emergentism: The Limited Grip of General Theory | 92 |
| The Interactive View: Theory-Based Structures Adjusted Empirically | 94 |
| Biological Understanding and Medical Treatment | 96 |
| Chronic Inflammation and Cancer | 98 |
| Individualized Medicine and the Limits of the Cascade Model | 102 |