Inflammation and Retinal Disease: Complement Biology and Pathology Complement Biology and Pathology
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John D. Lambris, Anthony P. Adamis
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John D. Lambris, Anthony P. Adamis
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Inflammation and Retinal Disease: Complement Biology and Pathology Complement Biology and Pathology
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Springer-Verlag
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9781441956354
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1
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CHF 190.00
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Klinische Fächer
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English
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170
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Wasserzeichen/DRM
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PC/MAC/eReader/Tablet
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PDF
Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference. Our sincere thanks to the contributing authors for the time and effort they have devoted to writing what I consider exceptionally informative chapters in a book that will have a significant impact on the complement field. We would also like to express my thanks to Rodanthi Lambris for her assistance in collating the chapters and preparing the documents for publication and I gratefully acknowledge the generous help provided by Dimitrios Lambris in managing the organization of this meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her supervision in this book's production. John D. Lambris Anthony P.
Preface
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Contents
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Contributors
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Chapter 1: The Case for Complement and Inflammationin AMD: Open Questions
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1 Introduction
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1.1 Epidemiology
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2 Drusen
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3 Geographic Atrophy
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4 Choroidal Neovascularization
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References
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Chapter 2: The Role of Complement in AMD
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1 Age-Related Macular Degeneration
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1.1 The Disease
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1.2 AMD: A Chronic Inflammatory Disease
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2 Age-Related Macular Degeneration: A Genetic Disorder
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3 Effect of the Reported SNPs for Protein Function
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3.1 Factor H and Other Complement Proteins
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3.1.1 Factor H and FHL1
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3.1.2 Complement Factor H Related Proteins
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3.1.3 Other Complement Proteins Associated with AMD: C2, Factor B and C3
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3.2 Gene Products of the Chromosome 10q26: ARMS-2 and HRTA1
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4 Lessons Learned from Rare Disorders (HUS, MPGN)
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5 Outlook
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References
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Chapter 3: Multiple Interactions of Complement Factor H with
