| Contents | 5 |
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| Contributors | 7 |
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| Introduction | 10 |
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| Part I Global Perspectives on Vector-Borne Disease | 12 |
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| The Role of Global Climate Patterns in the Spatial and Temporal Distribution of Vector-Borne Disease | 13 |
| Introduction | 13 |
| Methods | 14 |
| Results and Discussion | 15 |
| Development of Climatic Conditions in Fall 2006 | 15 |
| Forecasted and Reported Increased Disease Outbreaks | 16 |
| Conclusions | 21 |
| References | 22 |
| The DDT Story: Environmentalism Over Rights to Health and Life | 24 |
| Introduction | 24 |
| The First Uses of IRS | 24 |
| Impact of the Anti-insecticide Movement | 26 |
| Converging Ideologies | 28 |
| Failure of Public Health Advocacy | 30 |
| Failures of Malaria Control Policies | 31 |
| DDT, A Unique Public Health Tool and Still Needed | 32 |
| Failure to Find a DDT Substitute | 33 |
| Need for Advocacy for Public Health Use of Insecticides | 33 |
| References | 34 |
| Vector-Borne Diseases in the 21st Century: Counting Up or Counting Down? | 35 |
| References | 41 |
| Part II Emerging and Invasive Vector-Borne Diseases | 44 |
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| The Global Threat of Emergent/Re-emergent Vector-Borne Diseases | 45 |
| Introduction | 45 |
| The Reemergence of Epidemic Vector-Borne Diseases As Public Health Problems | 46 |
| Parasitic Diseases | 47 |
| Bacterial Diseases | 47 |
| Arboviral Diseases | 48 |
| West Nile Virus | 50 |
| Dengue/Dengue Hemorrhagic Fever | 55 |
| Yellow Fever | 57 |
| Why Has There Been Such a Dramatic Resurgence of Vector-Borne Diseases? | 60 |
| Lessons Learned and Challenges to Reverse the Trend | 62 |
| References | 65 |
| The Need for Synergy and Value Creation in Contemporary Vector Research and Control | 69 |
| Introduction | 69 |
| The Death of Creativity | 71 |
| Synergy and Value Creation | 72 |
| Architecture and Vector-Borne Disease Control | 75 |
| Genetically Modified Mosquitoes | 75 |
| Larval Control: Forgotten Successes | 77 |
| Synergy and Value Creation at Wageningen University | 78 |
| Identification of Attractants for Malaria Mosquitoes | 79 |
| Toward Biological Control of Adult Mosquito Vectors | 81 |
| The Achilles Heel of Malaria | 82 |
| Conclusions | 82 |
| References | 83 |
| Dramas Down-Under: Changes and Challenges in Australia | 86 |
| Introduction | 86 |
| Exotic Vectors | 87 |
| Exotic Pathogens | 89 |
| Emerging Indigenous Pathogens | 94 |
| The Alphaviruses: Barmah Forest Virus (BFV) | 94 |
| Conclusions | 96 |
| References | 97 |
| Part III Arboviruses and Their Control in the Field | 102 |
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| Novel Strategies to Control Aedes aegypti and Dengue | 103 |
| Introduction | 103 |
| Harnessing Vector Innate Immunity to Develop Dengue Resistant Ae. aegypti | 104 |
| RNAi Conditions Arbovirus Infection in Mosquitoes | 104 |
| Association Mapping Links Vector Competence of Ae. aegyptito the Vector Immune Response | 105 |
| Exploitation of the RNAi Response to Generate Transgenic Mosquitoes Immunologically Refractory to Dengue Virus Infection | 106 |
| The Casa Segura (Safe Home) A Novel Approach to Protect the Home from Aedes aegypti | 108 |
| A Dengue Decision Support System for Enhanced Vector Control and Prevention | 109 |
| Development of the Dengue Decision Support System (DDSS) | 110 |
| Syndromic Surveillance for Improved Dengue Control | 111 |
| Conclusions | 112 |
| References | 113 |
| Dengue Haemorrhagic Fever in Thailand: Current Incidence and Vector Management | 116 |
| Introduction | 116 |
| Incidence of DHF | 116 |
| Distribution of Dengue Viruses | 118 |
| DHF Vectors | 120 |
| Current DHF Vector Management | 121 |
| Country Obstacles and Challenges | 122 |
| Difficulty in Mobilizing Community Participation in Vector Control | 123 |
| Insufficient Supply of Materials Used for Vector Control | 124 |
| Lack of Good Management in Vector Control | 124 |
| Lack of Systematic Monitoring of Larval and Adult Resistance to the Insecticides Used | 125 |
| Conclusion | 125 |
| References | 126 |
| Using Mullas Formula to Estimate Percent Control | 129 |
| Introduction | 129 |
| Mullas Formula | 132 |
| Examples | 132 |
| Summary | 136 |
| References | 138 |
| Longitudinal Field Studies Will Guide a Paradigm Shift in Dengue Prevention | 140 |
| Introduction | 140 |
| Dengue Epidemiology and Ecology | 142 |
| Dengue Control | 143 |
| Establishing Goals for Dengue Prevention Programs | 145 |
| Recommendations for Improved Vector Control | 151 |
| The Paradigm Shift from Top-Down Direction to Local Level Decision | 152 |
| Box 1 Key Questions for Development of Innovative, Sustainable, and Cost-Effective Dengue Prevention | 151 |
| Surveillance and Control of Adult Versus Immature Mosquitoes | 153 |
| Emphasis on Intradomicile Vector Control | 154 |
| Integrated Disease Prevention: Vector Control and Vaccines | 155 |
| References | 156 |
| Recombinant Bacterial Larvicides for Control of Important Mosquito Vectors of Disease | 163 |
| Introduction | 163 |
| Basic Biology and Mode of Action of Bt and Bti | 164 |
| Basic Biology and Mode of Action of Bacillus sphaericus (Bs) | 167 |
| Current Usage | 167 |
| Genetic Regulation of Cry and Cyt Protein Synthesis | 168 |
| Construction of Recombinant Bacterial Larvicides | 168 |
| Safety Concerns About Wild Type and Recombinant Bacterial Insecticides | 173 |
| Conclusions | 174 |
| References | 175 |
| Part IV Pest Management and Outreach in Disease Ende
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