The Baboon in Biomedical Research
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Russell H. Tuttle, John L. VandeBerg, Sarah Williams-Blangero, Suzette D. Tardif
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John L. VandeBerg, Sarah Williams-Blangero, Suzette D. Tardif
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The Baboon in Biomedical Research
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Springer-Verlag
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9780387759913
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1
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CHF 135.40
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Zoologie
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English
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392
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Wasserzeichen/DRM
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PC/MAC/eReader/Tablet
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PDF
Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.
Preface
7
Contents
9
Contributors
11
Introduction
16
The Development and Status of the Baboon Genetic Linkage Map
23
Introduction
23
Early Linkage Studies in Macaques and Baboons
23
Initial Studies of Microsatellite Polymorphisms in Nonhuman Primates
24
Development of the Baboon Whole Genome Linkage Map
25
Current Status of the Baboon Linkage Map
26
Locating Quantitative Trait Loci Using the Baboon Linkage Map
37
Future Directions for Research
38
The Study of Captive Baboon Behavior
42
Introduction
42
A Primer on Baboon Behavior
43
Behavioral Measures of Baboons in Biomedical Research
43
The Study of Behavior
45
Behavioral Management of Captive Baboons
47
Spontaneous Pathology of Baboons
56
Introduction
56
Integumental System
63
Alimentary System
64
Genitourinary System
65
Central Nervous System
66
Musculoskeletal System
66
Hematopoietic and Lymphoid Systems
67
Cardiovascular System
68
Respiratory System
68
Endocrine System
69
Growth and Development of Baboons
77
Introduction
77
Materials and Methods
78
2.1 Materials
78
2.2 Methods
79
Results
82
