| CONTENTS | 5 |
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| EDITORS | 7 |
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| CONTRIBUTORS | 7 |
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| FOREWORD | 12 |
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| PREFACE | 13 |
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| Section I: Basic Pharmacology | 14 |
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| GABAa Receptor Subtypes in Sedation and Hypnosis | 15 |
| Sleep Hippocampal Theta Rhythm and sensory Processing | 22 |
| Monoamitiergic Mechanisms in the Regulation of Sleep- Wakefulness: Special Emphasis on Preoptic Noradrenergic System | 27 |
| REM Sleep Function and Brain Monoamine Regulation: An Application of the Search Activity Concept | 39 |
| Role of Wakefulness Area in the Brainstem Reticular Formation in Regulating Rapid Eye Movement Sleep | 48 |
| The Mechanistic Relationship between NREM Sleep and Anesthesia | 55 |
| Section II: Chronopharmacology | 65 |
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| Time- Dependent Psychotropic Drug Effects: Hints of Pharmacochronomics, Broader than Circadian Time Structures | 66 |
| Melatonin Interaction with BZ- GabaA Receptors: Implications for Sleep Induction | 107 |
| Melatonin: A Chronobiotic that Not Only Shifts Rhythms | 112 |
| Melatonin and Human Sleep | 119 |
| Melatonin Efficacy to Treat Circadian Alterations of Sleep in Alzheimer's Disease | 123 |
| Pharmacotherapy for Seasonal Affective Disorder | 133 |
| Use and Discontinuation of Hypnosedative Medications | 139 |
| Section III: Clinical Pharmacology | 145 |
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| Long- Term Use of Sleeping PiUs in Chronic Insomnia | 146 |
| Risks of Chronic Hypnotic Use | 152 |
| Meets of Psychotropics on Driving Performance | 157 |
| Diagnosis, Pathophysiology and Treatment of Hypersomnias | 162 |
| Chronic Disease and Sleep Architecture: Pharmacotherapeutic Considerations | 174 |
| Benzodiazepines for Sedation in Infants and Children | 181 |
| The Pharmacological Management of Fatigue and Sleepiness in Affective Disorders | 194 |
| Next- Day Residual EflFects of Sleeping Medications on Driving Ability: A Review of the Literature | 199 |
| Sleep and Pain | 212 |
| Head Injuries and Sleep | 221 |
| Psvchopharmacological Management of Restless Legs syndrome and Periodic Limb Movements in Sleep | 227 |
| A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient's Estimate of Sleep Quality | 231 |
| The Pharmacostrateey of Treating Sleep Disorders in Parkinsonism | 236 |
| The Neuropharmacology of Nightmares | 252 |
| The Night Eating Syndrome | 262 |
| Drug Effects on Dreaming | 267 |
| Sleep Problems in Primary Care | 273 |
| SSRIs and Sleep in Man | 280 |
| Sleep and Antipsychotic Drugs in Schizophrenia Patients | 285 |
| Sleep and Epilepsy: From Interrelationships to Influence of Antiepileptic Drugs | 293 |
| Herbal Medicines and Sleep | 308 |
| INDEX | 315 |