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Sepsis

:	Simon V. Baudouin
:	Simon V. Baudouin
:	Sepsis
:	Springer-Verlag
:	9781846289392
:	1
:	CHF 47.50
:

:	Klinische Fächer
:	English

:	103
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

Discover new, effective strategies to prevent and treat sepsis. In this book, leading medical experts consider how the pathways implicated in early and late sepsis interact. Next, the book describes numerous pharmacological approaches that enable you to provide state-of-the-technology care for patients in both early and late sepsis. You'll also get detailed discussions of how the various physiological systems function under sepsis.

	Contents	6
	Contributors	8
	1 Sepsis: Introduction and Epidemiology	10
	The Epidemiology of Sepsis	10
	Incidence and Occurrence of Sepsis	11
	Outcome from Sepsis	12
	Predictors of Outcome	12
	Changes in Microbiology Over Time	13
	The Economics of Sepsis	13
	Conclusion	13
	References	13
	2 Mechanisms of Innate Immunity in Sepsis	14
	The Innate Immune Response in Sepsis	14
	Triggering of Innate Immune Responses	15
	Toll-Like Receptors	15
	TLR Signaling	16
	Regulation of TLR Signaling	18
	Endotoxin Tolerance	18
	Clinical Directions	19
	References	19
	3 Metabolic and Endocrine Changes in Sepsis and the Catabolic State	20
	Sepsis and the Catabolic State	20
	Metabolic-Nutritional Responses to Sepsis and Critical Illness	20
	The Insulin-Glucose Axis in Sepsis and Critical Illness	21
	Endocrine Responses to Sepsis and Critical Illness	21
	Implications for Clinical Practice	24
	4 Hematological and Coagulation Changes in Sepsis	26
	Introduction	26
	Hematological Changes in Sepsis	26
	Coagulation Changes in Sepsis	28
	Disseminated Intravascular Coagulation	28
	Other Coagulation Changes in Sepsis	32
	Conclusion	32
	References	33
	5 The Genetics of Sepsis and Inflammation	35
	What Are Genetic Polymorphisms and How Can They Be Used to Investigate the Genetics of Sepsis?	35
	Genetic Association Studies in Sepsis	37
	Combinations of Polymorphisms	39
	Clinical Uses for Polymorphisms	39
	The Future	39
	6 Cardiac, Circulatory, and Microvascular Changes in Sepsis and Multiorgan Dysfunction Syndrome	41
	Cardiovascular Effects of Sepsis	41
	Cardiovascular Support in Sepsis	44
	Microcirculation and Cellular Considerations in Sepsis	45
	Summary	47
	References	47
	7 Specific Bacterial Infections in the Immunocompetent Patient	49
	Meningococcal Disease	49
	b-Hemolytic Streptococci	51
	Toxic Shock Syndrome	52
	Surgical Infections	54
	8 Infection in the Immunocompromised Patient	56
	Increased Susceptibility to Infection	56
	Management of Granulocytopenic Sepsis	58
	Humoral Immunodeficiency	60
	CMV Infection in Transplant Recipients	60
	Pneumocystis Jiroveci Pneumonia	62
	Diagnosis	63
	9 Severe Infections in the Returning Traveler	65
	Severe and Complicated Malaria	65
	SARS as an Example of an Emerging Contagious Disease with High Morbidity and Mortality	67
	Viral Hemorrhagic Fever	69
	Summary	71
	10 Antibiotic Prescribing Including Antibiotic Resistance	72
	Important Antibiotics and their Use in the Critical Care Setting	72
	Principles of Choice of Antimicrobial Agent	74
	Principles for Prescribing Antimicrobial Agents	74
	Antibiotic Resistance	76
	Current Therapeutic Problems in ITU	77
	Summary	78
	11 Infection Control in the Intensive Care Unit	79
	General Principles	79
	Means of Transmission of Infection	79
	Patient Isolation	80
	Universal Precautions	80
	Specific Problems	81
	Conclusions	85
	12 Randomized Controlled Trials in Sepsis	87
	Management of the Proinflammatory Response	87
	Management of the Metabolic Response	89
	Management of the Procoagulant Response	90
	Standard Resuscitation	92
	Conclusions	94
	13 Guidelines, Protocols, and the Surviving Sepsis Guidelines: A Critical Appraisal	96
	What is the Purpose of Guidelines?	96
	Why do Guidelines Fail?	96
	Conclusion	100
	14 Practical Approaches to the Patient with Severe Sepsis: Illustrative Case Histories	102
	Illustrative Cases	103
	Practical Tips and Avoiding Pitfalls	106
	Conclusions	107
	References	107
	Index	108