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Arterial Chemoreceptors Arterial Chemoreceptors

:	Nathan Back, Irun R. Cohen, Abel Lajtha, John D. Lambris, Rodolfo Paoletti, Constancio Gonzalez
:	Constancio Gonzalez, Colin A. Nurse, Chris Peers
:	Arterial Chemoreceptors Arterial Chemoreceptors
:	Springer-Verlag
:	9789048122592
:	1
:	CHF 190.00
:

:	Nichtklinische Fächer
:	English

:	455
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

This book offers an updated review of the physiology of the carotid body chemoreceptors. It provides the trends in the field as it contains results in the topics that are at the frontiers of future developments in O₂-sensing in chemoreceptor cells.

	Preface	6
	Contents	8
	Contributors	16
	The Discovery of Sensory Nature of the Carotid Bodies Invited Article	25
	1 Introduction	26
	2 De Castro, 1926	27
	3 De Castro, 1928	29
	4 Heymans in the 1930 s and the Nobel Prize in Physiology or Medicine	33
	5 The Scientific Path of Fernando De Castro Between 1929 and 1936	35
	6 Corneille Heymans, Nobel Prize in Physiology or Medicine in 1938	37
	7 Heymans and De Castro: A History of Mutual Admiration	40
	References	40
	Fifty Years of Progress in Carotid Body Physiology Invited Article	43
	1 Prolegomena	43
	2 Organization of the Carotid Body	44
	3 Testing Carotid Body Physiological Responses	44
	4 Glomus Cell Responses to Chemical Stimuli	45
	5 Chemical Transmission Between Glomus Cells and Chemosensory Nerve Endings	46
	6 Chemoreflexes Originated from the Carotid Bodies	48
	7 Concluding Remarks	49
	References	51
	Carotid Body: New Stimuli and New Preparations Invited Article	53
	1 Introduction	53
	2 Co-Culture Preparations of Rat Carotid Body	54
	3 Electrophysiological Experiments on Carotid Body Co-Cultures	57
	4 Carotid Body Slice Preparation	58
	5 The Carotid Body as a Glucosensor: Contributions from Slice and Co-Culture Preparations	60
	6 Transgenic Mouse Models	61
	References	61
	Enzyme-Linked Acute Oxygen Sensing in Airway and Arterial Chemoreceptors Invited Article	63
	1 Introduction	63
	2 NADPH Oxidase	64
	3 Hemeoxygenase	67
	4 AMP-Activated Kinase	68
	5 Conclusions	69
	References	70
	Cysteine Residues in the C-terminal Tail of the Human BKCaa Subunit Are Important for Channel Sensitivity to Carbon Monoxide	72
	1 Introduction	73
	2 Materials and Methods	73
	3 Results and Discussion	74
	References	78
	Modulation of O2 Sensitive K+ Channels by AMP-activated Protein Kinase	80
	1 Introduction	80
	2 Methods	81
	3 Results	82
	4 Discussion	84
	References	86
	Hydrogen Sulfide Inhibits Human BKCa Channels	87
	1 Introduction	88
	2 Materials and Methods	88
	3 Results and Discussion	90
	References	93
	DPPX Modifies TEA Sensitivity of the Kv4 Channels in Rabbit Carotid Body Chemoreceptor Cells	95
	1 Introduction	95
	2 Methods	96
	3 Results	98
	4 Discussion	102
	References	103
	Sustained Hypoxia Enhances TASK-like Current Inhibition by Acute Hypoxia in Rat Carotid Body Type-I Cells	105
	1 Introduction	105
	2 Methods	106
	3 Results	107
	4 Discussion	108
	5 Conclusion	109
	References	109
	Inhibition of L-Type Ca2+ Channels by Carbon Monoxide	111
	1 Introduction	111
	2 Methods	112
	3 Results	113
	4 Discussion	115
	References	116
	Effects of the Polyamine Spermine on Arterial Chemoreception	118
	1 Introduction	119
	2 Methods	119
	3 Results and Discussion	121
	References	124
	RT-PCR and Pharmacological Analysis of L-and T-Type Calcium Channels in Rat Carotid Body	126
	1 Introduction	127
	2 Methods	127
	3 Results	129
	4 Discussion	130
	References	133
	Functional Characterization of Phosphodiesterases 4 in the Rat Carotid Body: Effect of Oxygen Concentrations	134
	1 Introduction	134
	2 Methods	135
	3 Results	136
	4 Discussion	137
	References	140
	Calcium Sensitivity for Hypoxia in PGNs with PC-12 Cells in Co-Culture	141
	1 Introduction	141
	2 Methods	142
	3 Results and Discussion	142
	References	144
	Modification of Relative Gene Expression Ratio Obtained from Real Time qPCR with Whole Carotid Body by Using Mathematical Equations	145
	1 Introduction	146
	2 Methods	146
	3 Results	148