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Hot Topics in Infection and Immunity in Children V

:	Adam Finn, Nigel Curtis, Andrew J. Pollard
:	Adam Finn, Nigel Curtis, Andrew J. Pollard
:	Hot Topics in Infection and Immunity in Children V
:	Springer-Verlag
:	9780387798387
:	1
:	CHF 133.00
:

:	Klinische Fächer
:	English

:	266
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

Course covers topics in infectious diseases in children and is intended for Pediatric Infectious disease trainees, trainers, and all those who manage children with infections.

This conference is being supported by several societies and is sponsored by several pharmaceutical companies, such as Aventis, Baxter, Chiron Vaccines, Wyeth, etc.

	Preface	6
	Acknowledgments	7
	Contents	8
	Contributors	10
	Shiga-Toxin Producing Escherichia coli and the Hemolytic Uremic Syndrome: What Have We Learned in the Past 25 Years?	14
	1 Introduction	14
	2 History	15
	3 Epidemiology of E. coli O157:H7 Infections and HUS	15
	4 Clinical Course of E. coli Infection	16
	5 Pathophysiology of E. coli O157:H7 Infections	17
	6 Diagnostic Considerations for Pathogenic STEC	17
	7 Management of Patients with Confirmed or Suspected E. coli O157:H7 Infection	19
	8 HUS and the Course of E. coli O157:H7 Infections	21
	9 Pathophysiology of HUS	23
	10 Conclusions	25
	References	26
	Global Epidemiology of Pneumococcal Disease-New Prospects for Vaccine Control	31
	1 Overview of the Pneumococcus and Pneumococcal Disease	31
	2 Pneumonia	32
	3 Invasive Pneumococcal Disease	32
	4 Acute Otitis Media	34
	5 Pneumococcal Vaccines	35
	6 The Power of Pneumococcal Conjugate Vaccines I: Effect of PCV-7 on Rates of IPD in the US after Introduction in 2000	36
	7 The Power of Pneumococcal Conjugate Vaccines II: Effect of the 11-Valent PHiD-Conjugate Vaccine on AOM in a Phase III Efficacy Trial	37
	8 Pneumococcal Vaccines for Adults	38
	9 Conclusions	38
	References	39
	Current Concepts of the Pathogenesis of RSV Bronchiolitis	42
	1 Introduction	42
	2 Genetic Determinants of RSV Bronchiolitis and Post-bronchiolitis Wheeze	43
	3 Pre-existent Airway Morbidity	45
	4 Immature Immune Responses	45
	5 Immunopathogenesis	46
	6 Parallel Versus Serial Hypothesis	47
	7 Conclusions	48
	References	48
	How Can We Eradicate Pertussis	52
	1 Introduction	52
	2 Bordetella pertussis: The Organism and Its Pathogenesis	52
	3 Clinical Disease	53
	3.1 Pertussis in Young Infants	54
	3.2 Adults	54
	4 Laboratory Diagnosis of B. pertussis Infection	55
	4.1 Culture	55
	4.2 Direct Detection of B. pertussis	55
	4.3 Serologic Diagnosis of B. pertussis Infection	55
	5 Epidemiology	56
	5.1 Reported Pertussis	56
	5.2 Epidemiology of B. pertussis Infections	57
	6 Vaccines	59
	7 Conclusions	61
	References	61
	Recognition and Management of Encephalitis in Children	63
	1 Introduction	63
	2 History	63
	3 Etiology	64
	4 Postimmunization Neurological Disease	66
	5 Postinfectious Encephalitis	66
	6 Chronic Encephalitic or Encephalopathic Illnesses (Slow Infections)	67
	7 Encephalitis Epidemiology	67
	8 Clinical Manifestations	67
	9 Differential Diagnosis	68
	10 Specific Diagnosis	68
	11 Treatment	69
	12 Prognosis	70
	13 Prevention	70
	References	70
	Microbiology and Management of Pleural Empyema	71
	1 Introduction	71
	2 Epidemiology and Aetiology	72
	2.1 Epidemiology	72
	2.2 Aetiology	72
	2.3 Risk Factors for Progression to Empyema	73
	3 Potential Reasons for Increasing Incidence of Empyema	74
	3.1 Serotype 1	74
	3.2 Sequence Types	74
	4 Management	75
	4.1 Prevention	75
	4.2 Drainage of Fluid	75
	5 Summary	76
	References	77
	Pneumococcal Conjugate Vaccines Probe Studies: The Solution Points to the Problem	79
	1 Observed Versus Expected Effect of a Vaccine - The Vaccine Probe Concept	79
	2 Vaccine Probe-Derived Insights into PCVs - Selected Examples	80
	2.1 Probe Studies in Pneumonia - the pneumonia detective	80
	3 Potential Role of PCVs in the Prevention of Mortality in Developing Populations	82
	4 Indirect Effect of PCV - the Herd Immunity Effect	82
	5 How Many Doses of PCV Are Appropriate for Infant Immunization Programs?	83
	6 Hypothesis Generating Results: A Study on Social Mixing During Infancy and Antibody Response to PCV7 at 1 Year of Age	85
	7 Conclusions	85
	References	86
	New Findings in Primary Immunodeficiency	88
	1 Introduction	88
	2 Severe Combined Immunodeficiency	88
	2.1 New T Lymphocyte Receptor Signalling Defects	90
	2.1.1 CD3 zeta Subunit Deficiency	90
	2.1.2 ORAI Deficiency	90
	2.2 New Defects of T and B Lymphocyte Receptor Recombination	90
	2.2.1 DNA Ligase IV Deficiency	90
	2.2.2 Cernunnos-XLF Deficiency	91
	3 X-Linked Lymphoproliferative Syndromes	91
	4 Common Variable Immunodeficiency	92
	4.1 Inducible Costimulator Deficiency	92
	4.2 CD19 Deficiency	92
	4.3 Transmembrane Activator and Calcium-Modulating Cyclophilin Lig