| Preface | 5 |
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| Acknowledgements | 7 |
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| Contents | 8 |
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| 1 Normal Cutaneous Histology | 12 |
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| Basic Skin Anatomy | 12 |
| Epidermis | 12 |
| Keratinocytes | 12 |
| Stratum Corneum | 13 |
| Stratum Granulosum | 14 |
| Stratum Spinosum | 14 |
| Stratum Basalis | 15 |
| Melanocytes | 16 |
| Langerhans Cells | 17 |
| Merkel Cells | 19 |
| Epidermal Appendages | 19 |
| Hair Follicles | 19 |
| Hair Follicle Anatomy (Anagen Phase) | 20 |
| Sebaceous Glands | 23 |
| Eccrine Glands | 24 |
| Eccrine Ducts | 25 |
| Apocrine Glands | 27 |
| Basement Membrane Zone | 27 |
| Basal Keratinocyte | 29 |
| Lamina Lucida | 29 |
| Lamina Densa | 30 |
| Sub lamina Densa | 30 |
| Dermis | 30 |
| Vasculature | 31 |
| Collagens | 33 |
| Elastic Tissue | 34 |
| Nerves | 35 |
| Muscles | 37 |
| Dermal Dendrocytes | 38 |
| Lymphocytes | 39 |
| Mast Cells | 39 |
| Fibroblasts | 40 |
| Subcutaneous Fat | 40 |
| Skin of Special Sites | 41 |
| 2 How to Maximize Information from a Skin Biopsy | 47 |
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| Presumed Neoplastic Processes | 48 |
| What is the Differential Diagnosis? | 48 |
| Are the Margins Important? | 49 |
| Melanocytic Neoplasms | 50 |
| Keratinocytic Neoplasms | 51 |
| Adnexal Neoplasms | 53 |
| Dermal Neoplasms | 56 |
| Hematopoietic Neoplasms | 59 |
| Inflammatory Processes | 60 |
| Blistering Diseases | 60 |
| ''Dermatitis'' and ''Rash'' | 62 |
| Infectious diseases | 63 |
| Connective Tissue Diseases | 66 |
| Direct Immunofluorescence | 67 |
| Vasculitis | 67 |
| Panniculitis | 68 |
| Alopecia | 69 |
| Miscellaneous Conditions | 70 |
| Presumed Connective Tissue Nevus, Anetoderma, Epidermal Nevus | 70 |
| Rules of Thumb | 70 |
| 3 Special Stains in Dermatopathology | 72 |
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| Histochemical Stains | 72 |
| Commonly Used Special Stains | 72 |
| Periodic Acid-Schiff (PAS) | 72 |
| PAS Uses | 73 |
| Alcian Blue | 73 |
| Alcian Blue/Colloidal Iron Uses | 74 |
| Elastic von Gieson | 74 |
| Von Gieson Uses | 74 |
| Brown and Brenn Stain | 75 |
| Acid Fast Stain (AFB) | 75 |
| Fite Stain | 76 |
| Giemsa | 76 |
| Giemsa Uses | 76 |
| Warthin-Starry | 77 |
| Massons Trichrome | 77 |
| Congo Red | 78 |
| Fontana Stain for Melanin | 80 |
| Chloroacetate Esterase | 80 |
| Perls | 81 |
| 4 Immunopathology in Diagnostic*5ptDermatopathology | 83 |
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| Tool Box: Antibody Panel | 83 |
| What Is a Tool Box? | 83 |
| Epithelial Markers | 83 |
| Mesenchymal Markers | 86 |
| Neuroectodermal Markers | 87 |
| Hematopoietic Markers | 89 |
| Miscellaneous Markers | 91 |
| Requirements for Interpretation | 93 |
| Pitfalls in Interpretation | 93 |
| Strategy for Immunopathology | 94 |
| Immunopathology | 96 |
| 5 Differential Diagnosis of Normal Skin | 100 |
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| Tinea Versicolor | 101 |
| Ichthyoses | 103 |
| Ichthyosis (X-Linked) | 103 |
| Ichthyosis (Lamellar) | 104 |
| Erythrasma | 104 |
| Ichthyosis Vulgaris | 107 |
| Pemphigus Foliaceus/Erythematosus | 108 |
| Vitiligo | 109 |
| Caf-Au-Lait Macule | 111 |
| Nevus Depigmentosus (Nevus Achromicus) | 111 |
| Connective Tissue Nevus | 113 |
| Cutis Laxa | 115 |
| Morphea | 117 |
| Anetoderma (Macular Atrophy, Focal Dermal Elastolysis) | 120 |
| Wrinkling due to Mid-dermal Elastolysis | 121 |
| Dermal Deposition Disorders | 121 |
| Amyloidosis | 122 |
| Localized Cutaneous Amyloidosis | 122 |
| Pretibial Myxedema | 124 |
| Sclerodema | 126 |
| Scleromyxedema | 128 |
| Nephrogenic Systemic Fibrosis | 128 |
| Conditions with Minimal Inflammation | 131 |
| Small Plaque (Guttate) Parapsoriasis (Digitate Dermatosis) | 131 |
| Urticaria | 133 |
| Urticaria Pigmentosa | 133 |
| Further Reading | 1 |
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| Index | 1 |