: Bruce R. Smoller, Kim M. Hiatt
: Dermatopathology: The Basics
: Springer-Verlag
: 9781441900241
: 1
: CHF 48.80
:
: Klinische Fächer
: English
: 156
: DRM
: PC/MAC/eReader/Tablet
: PDF

Dermatopath logy: The Basics serves as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The reader is able to focus upon a single histologic observation, i.e., inflammatory conditions without epidermal changes, and use this as a starting point from which to build a differential diagnosis based upon pattern recognition. As each entity is addressed, there is a concise discussion of the basic clinical findings and epidemiologic associations. This is followed by a histologic description, highlighting areas that serve to discriminate between the entity under discussion and similar ones. Any immunologic studies that might augment the diagnostic sensitivity or specificity are discussed.

Chapters are thematically based and consist of essential bullet points arranged in organized outlines allowing for easy access and direct comparison between entities. The salient histologic features are depicted with abundant high quality, full-color photomicrographs placed immediately adjacent to the appropriate histologic bullet points. This volume serves as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The elaborate pictorial documentation serves as an atlas of the commonest dermatologic disorders.

 

Preface5
Acknowledgements7
Contents8
1 Normal Cutaneous Histology12
Basic Skin Anatomy12
Epidermis12
Keratinocytes12
Stratum Corneum13
Stratum Granulosum14
Stratum Spinosum14
Stratum Basalis15
Melanocytes16
Langerhans Cells17
Merkel Cells19
Epidermal Appendages19
Hair Follicles19
Hair Follicle Anatomy (Anagen Phase)20
Sebaceous Glands23
Eccrine Glands24
Eccrine Ducts25
Apocrine Glands27
Basement Membrane Zone27
Basal Keratinocyte29
Lamina Lucida29
Lamina Densa30
Sub lamina Densa30
Dermis30
Vasculature31
Collagens33
Elastic Tissue34
Nerves35
Muscles37
Dermal Dendrocytes38
Lymphocytes39
Mast Cells39
Fibroblasts40
Subcutaneous Fat40
Skin of Special Sites41
2 How to Maximize Information from a Skin Biopsy47
Presumed Neoplastic Processes48
What is the Differential Diagnosis?48
Are the Margins Important?49
Melanocytic Neoplasms50
Keratinocytic Neoplasms51
Adnexal Neoplasms53
Dermal Neoplasms56
Hematopoietic Neoplasms59
Inflammatory Processes60
Blistering Diseases60
''Dermatitis'' and ''Rash''62
Infectious diseases63
Connective Tissue Diseases66
Direct Immunofluorescence67
Vasculitis67
Panniculitis68
Alopecia69
Miscellaneous Conditions70
Presumed Connective Tissue Nevus, Anetoderma, Epidermal Nevus70
Rules of Thumb70
3 Special Stains in Dermatopathology72
Histochemical Stains72
Commonly Used Special Stains72
Periodic Acid-Schiff (PAS)72
PAS Uses73
Alcian Blue73
Alcian Blue/Colloidal Iron Uses74
Elastic von Gieson74
Von Gieson Uses74
Brown and Brenn Stain75
Acid Fast Stain (AFB)75
Fite Stain76
Giemsa76
Giemsa Uses76
Warthin-Starry77
Massons Trichrome77
Congo Red78
Fontana Stain for Melanin80
Chloroacetate Esterase80
Perls81
4 Immunopathology in Diagnostic*5ptDermatopathology83
Tool Box: Antibody Panel83
What Is a Tool Box?83
Epithelial Markers83
Mesenchymal Markers86
Neuroectodermal Markers87
Hematopoietic Markers89
Miscellaneous Markers91
Requirements for Interpretation93
Pitfalls in Interpretation93
Strategy for Immunopathology94
Immunopathology96
5 Differential Diagnosis of Normal Skin100
Tinea Versicolor101
Ichthyoses103
Ichthyosis (X-Linked)103
Ichthyosis (Lamellar)104
Erythrasma104
Ichthyosis Vulgaris107
Pemphigus Foliaceus/Erythematosus108
Vitiligo109
Caf-Au-Lait Macule111
Nevus Depigmentosus (Nevus Achromicus)111
Connective Tissue Nevus113
Cutis Laxa115
Morphea117
Anetoderma (Macular Atrophy, Focal Dermal Elastolysis)120
Wrinkling due to Mid-dermal Elastolysis121
Dermal Deposition Disorders121
Amyloidosis122
Localized Cutaneous Amyloidosis122
Pretibial Myxedema124
Sclerodema126
Scleromyxedema128
Nephrogenic Systemic Fibrosis128
Conditions with Minimal Inflammation131
Small Plaque (Guttate) Parapsoriasis (Digitate Dermatosis)131
Urticaria133
Urticaria Pigmentosa133
Further Reading1
Index1