| MEDICAL RADIOLOGY Diagnostic Imaging | 2 |
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| A. M. Davies · M. Sundaram · S. L. J. James (Eds.) | 3 |
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| Techniques and Applications | 3 |
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| Foreword | 5 |
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| Preface | 6 |
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| Contents | 7 |
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| Bone Tumors: Epidemiology, Classification, Pathology | 11 |
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| Introduction | 12 |
| Epidemiology | 12 |
| Morphologic Diagnosis of Bone Tumors | 15 |
| Types of Bone Tumor Specimens | 16 |
| Adjunctive Diagnostic Techniques | 17 |
| Classification of Bone Tumors | 17 |
| Comments on the Morphologic Classification of Bone Tumors | 17 |
| Congenital, Hereditary, and Non-hereditary Syndromes Associated with Bone Tumors | 24 |
| References | 24 |
| Computed Tomography of Bone Tumours | 26 |
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| Introduction | 26 |
| Developments in Computed Tomography | 27 |
| Scan Image Quality | 29 |
| CT of Bone Tumours | 33 |
| Indications | 33 |
| CT-Guided Interventions | 35 |
| Conclusion | 37 |
| References | 37 |
| Imaging Techniques: Magnetic Resonance Imaging | 39 |
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| Introduction | 40 |
| Technical Considerations | 40 |
| 3.2.2.1 T1-weighted SE | 41 |
| 3.2.2.2 T2-weighted Fast SE | 42 |
| 3.2.2.3 Gadolinium-enhanced SE | 43 |
| 3.2.2.4 Gradient Echo | 45 |
| 3.2.2.5 STIR | 46 |
| 3.2.4.1 Signal-to-Noise Ratio | 47 |
| 3.2.4.2 Spatial Resolution | 48 |
| 3.2.4.3 Scan Time | 48 |
| 3.2.6.1 Quantitative Dynamic MR Imaging | 48 |
| 3.2.6.2 Diffusion-weighted Imaging | 49 |
| 3.2.6.3 MR Spectroscopy | 50 |
| Common MR Imaging Artifacts | 50 |
| Overview of MR Imaging in Bone Tumors | 54 |
| 3.4.1.1 Fluid | 55 |
| 3.4.1.2 Fluid-fluid levels | 55 |
| 3.4.1.3 Edema | 55 |
| 3.4.1.4 Hemorrhage | 57 |
| 3.4.1.5N ecrosis | 59 |
| References | 59 |
| Nuclear Medicine | 61 |
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| Introduction | 62 |
| PET and PET/CT | 82 |
| 4.3.2.1 The Diagnosis and Grading of Bone Tumours | 84 |
| 4.3.2.2 Staging of Sarcomas | 85 |
| 4.3.2.3 Prognostic Indicator and Response to Therapy | 86 |
| 4.3.2.4 Recurrence and Metastatic Disease | 87 |
| 4.3.2.5 | 89 |
| 4.3.2.6 | 89 |
| and PET/CT | 89 |
| References | 90 |
| Ultrasonography | 93 |
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| Introduction | 93 |
| Imaging Features of Bone Tumours on Ultrasound | 94 |
| Morphological Features of Bone Tumours on Ultrasound | 94 |
| Tumour Characterisation | 97 |
| US-Guided Biopsy | 98 |
| Monitoring of Tumour Response | 99 |
| Assessment of Local Recurrence | 100 |
| Conclusion | 101 |
| References | 101 |
| Interventional Techniques | 102 |
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| Introduction | 102 |
| Thermal Ablation | 103 |
| Cementoplasty | 106 |
| Bone Substitutes | 112 |
| Embolization | 113 |
| References | 114 |
| Principles of Detection and Diagnosis | 117 |
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| Introduction | 117 |
| Detection | 118 |
| Diagnosis | 123 |
| 7.3.1.1 Site in Skeleton | 125 |
| 7.3.1.2 Location in Bone | 126 |
| 7.3.1.3 Pattern of Bone Destruction | 130 |
| 7.3.1.4 Periosteal Reaction | 132 |
| 7.3.1.5 Tumour Mineralisation | 137 |
| Conclusion | 141 |
| References | 141 |
| Biopsy | 144 |
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| Introduction | 145 |
| Planning of Biopsy | 145 |
| 8.2.2.1 Lesion Selection | 148 |
| 8.2.2.2 Biopsy Method | 148 |
| 8.2.3.1 Fluoroscopy | 151 |
| 8.2.3.2 Ultrasonography | 151 |
| 8.2.3.3 MR Imaging | 152 |
| 8.2.3.4 CT Fluoroscopy | 152 |
| 8.2.4.1 Axial Skeleton | 153 |
| 8.2.4.2 Appendicular Skeleton | 154 |
| Procedure | 159 |
| 8.3.3.1 US-Guided Biopsy | 160 |
| 8.3.3.2 CT-Guided Biopsy | 160 |
| 8.3.3.3 Spinal Biopsy | 162 |
| Conclusion | 165 |
| References | 165 |
| Surgical Staging 1: Primary Tumour | 168 |
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| Introduction |
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