Non-Protein Coding RNAs
:
Nils G. Walter, Sarah A. Woodson, Robert T. Batey
:
Nils Walter, Sarah A. Woodson, Robert T. Batey
:
Non-Protein Coding RNAs
:
Springer-Verlag
:
9783540708407
:
1
:
CHF 189.80
:
:
Biochemie, Biophysik
:
English
:
398
:
Wasserzeichen/DRM
:
PC/MAC/eReader/Tablet
:
PDF
The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, Andrew Fire and Craig Mello. This prize, which follows 'RNA' Nobels for splicing and RNA catalysis, highlights just one class of recently discovered non-protein coding RNAs. Remarkably, non-coding RNAs are thought to outnumber protein coding genes in mammals by perhaps as much as four-fold. In fact, it appears that the complexity of an organism correlates with the fraction of its genome devoted to non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic tra- posons, higher-level organization of eukaryotic chromosomes, and gene expression are found to be largely directed by non-protein coding RNAs. Currently, bioinformatic, high-throughput sequencing, and biochemical approaches are identifying an increasing number of these RNAs. Unfortunately, our ability to characterize the molecular details of these RNAs is significantly lacking. The biophysical study of these RNAs is an emergent field that is unraveling the molecular underpinnings of how RNA fulfills its multitude of roles in sustaining cellular life. The resulting understanding of the physical and chemical processes at the molecular level is critical to our ability to harness RNA for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry.
Prelims.pdf
1
Walter_Preface.pdf
4
Walter_TOC.pdf
6
Walter_LOC.pdf
8
Walter_01.pdf
11
Walter_02.pdf
37
Walter_03.pdf
58
Walter_04.pdf
82
Walter_05.pdf
112
Walter_06.pdf
137
Walter_07.pdf
152
Walter_08.pdf
174
Walter_09.pdf
190
Walter_10.pdf
221
Walter_11.pdf
235
Walter_12.pdf
254
Walter_13.pdf
277
Walter_14.pdf
289
Walter_15.pdf
306
Walter_16.pdf
320
Walter_17.pdf
337
Walter Index.pdf
359
