: Peter H. St. George-Hyslop, William C. C. Mobley, Yves Christen
: Peter H. St.George-Hyslop, William C. Mobley
: Intracellular Traffic and Neurodegenerative Disorders
: Springer-Verlag
: 9783540879411
: 1
: CHF 190.00
:
: Nichtklinische Fächer
: English
: 184
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.
Foreword6
Acknowledgements8
Contents9
Contributors11
Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms15
Intramembrane Proteolysis by . -Secretase and Signal Peptide Peptidases24
Axonal Transport and Neurodegenerative Disease40
Simple Cellular Solutions to Complex Problems53
Tau and Intracellular Transport in Neurons70
Signaling Between Synapse and Nucleus During Synaptic Plasticity82
Axonal Transport of Neurotrophic Signals: An Achilles’ Heel for Neurodegeneration?97
Membrane Trafficking and Targeting in Alzheimer’s Disease112
Huntington’s Disease: Function and Dysfunction of Huntingtin in Axonal Transport123
The Role of Retromer in Neurodegenerative Disease132
Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role in Neurodegenerative Disease148
The Sortilin-Related Receptor SORL1 is Functionally and Genetically Associated with Alzheimer’s Disease163
Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA172
Index185