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2nd International Workshop on Practical Applications of Computational Biology and Bioinformatics (IWPACBB 2008)

:	J. Kacprzyk, Juan M. Corchado, Juan F. Paz, Miguel P. Rocha, Florentino Fernández Riverola
:	Juan Manuel Corchado Rodríguez, Francisco de Paz, Miguel P. Rocha, Florentino Fernández Riverola
:	2nd International Workshop on Practical Applications of Computational Biology and Bioinformatics (IWPACBB 2008)
:	Springer-Verlag
:	9783540858614
:	Advances in Intelligent and Soft Computing
:	1
:	CHF 132.70
:

:	Allgemeines, Lexika
:	English

:	254
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

The success of Bioinformatics in recent years has been prompted by research in mole- lar biology and medicine in initiatives like the human genome project. The volume and diversification of data has increased so much that it is very hard if not impossible to analyze it by human experts. The analysis of this growing body of data, intensified by the development of a number of high-throughput experimental techniques that are generating the so called 'omics' data, has prompted for new computational methods. New global approaches, such as Systems Biology, have been emerging replacing the reductionist view that dominated biology research in the last decades, requiring the coordinated efforts of biological researchers with those related to data analysis, mathematical modelling and computer science. Computational methods have been helping in tasks related to knowledge discovery, modelling and optimization tasks. This workshop brings the opportunity to discuss applications of Bioinformatics and Computational Biology exploring the interactions between computer scientists, bio- gists and other scientific researchers. The IWPACBB technical program includes 29 papers (23 long papers and 6 short papers) selected from a submission pool of 51 papers, from 9 different countries. We thank the excellent work of the local organization members and also from the members of the Program Committee for their excellent reviewing work. October 2008 Juan M. Corchado Juan F. De Paz Miguel P. Rocha Florentino Fernández Riverola Organization

	Title Page	2
	Preface	6
	Organization	7
	Contents	9
	Comparing Time Series through Event Clustering	13
	Introduction	13
	Related Work	15
	Proposed Method	16
	Results	19
	Conclusions	20
	References	20
	Visual Knowledge-Based Metaphors to Support the Analysis of Polysomnographic Recordings	22
	Introduction	22
	Prior Definitions	23
	Providing Support for the Identification of Apneas and Hypopneas	24
	The Algorithm	25
	The Visual Metaphor	27
	Providing Support for the Identification of Desaturations	27
	The Algorithm	28
	The Visual Metaphor	29
	Experimental Results	29
	Discussion	30
	Conclusions	31
	References	32
	A Bio-inspired Proposal for Focus Attention While Preserving Information	33
	Introduction: The Problem of Visual Attention	33
	Computational Aspects of the Visual Attention Process	34
	Layered Computation	34
	Presynaptic Inhibition Schemes	35
	Convergence and Divergence of Information Process	36
	Complete Transforms	36
	The Proposed Model: Focus Attention While Preserving Information	37
	Conclusions	40
	References	40
	Modelling Fed-Batch Fermentation Processes: An Approach Based on Artificial Neural Networks	42
	Introduction	42
	Modelling Fermentation Processes	43
	Description of the Computational Tools	44
	Methodology	44
	White Box Interface	45
	Grey Box Interface	46
	Case Studies	47
	PR Process	47
	Ecoli Process	47
	Methodology	48
	Results	48
	PR	48
	Ecoli	49
	Conclusions and Further Work	50
	References	50
	New Principles and Adequate Control Methods for Insulin Dosage in Case of Diabetes	52
	Introduction	52
	New Modelling Concepts for Type I Diabetes	54
	Robust Control Methods for Optimal Insulin Dosage in Case of Type I Diabetic Patients	54
	Symbolic Computation-Based Robust Algorithms with $Mathematica$	54
	References	55
	A Framework for CBR Development and Experimentation with Application to Medical Diagnosis	57
	Introduction	57
	eXiT*CBR Framework	58
	Pre-processing Module	60
	Retrieve Module	60
	Reuse Module	60
	Revise Module	61
	Retain Module	61
	Experimentation Module	61
	Post-processing Module	61
	eXiT*CBR Functionalities	62
	Application to Breast Cancer Diagnosis	63
	Related Work	63
	Conclusions	64
	References	65
	Identification of Relevant Knowledge for Characterizing the Melanoma Domain	67
	Introduction	67
	Related Work	68
	Melanoma Framework	68
	Discussion	70
	Conclusions and Further Work	70
	References	71
	TAT-NIDS: An Immune-Based Anomaly Detection Architecture for Network Intrusion Detection	72
	Introduction	72
	TheTATModel	74
	TAT-Based NIDS	74
	The Framework	74
	The Algorithm	76
	Results	77
	Conclusions	78
	References	78
	Novel Computational Methods for Large Scale Genome Comparison	80
	Introduction	80
	Multiple Genome Alignment of Closely Related Species	81
	Local Multiple Alignment of Interspersed Repeats	81
	Comparative Genomics Case Study of DUS in $Neisseria$	82
	Conclusion	83
	References	84
	Improving Literature Searches in Gene Expression Studies	86
	Introduction	86
	Extracting Knowledge from DNA Microarray Data	87
	Proposed Workflow	89
	Acquiring, Mapping and Validating Genes Identifiers	89
	Using Query Expansion Techniques	90
	Searching over PubMed	90
	Assembling the Results	91
	System Implementation and Avaibility	91
	Discussion	92
	Conclusion	93
	References	93
	Implementing an Interactive Web-Based DAS Client	95
	Introduction	95
	The Distributed Annotation System	96
	DASGenExp	96
	Implementation	97
	The Client	98
	The Server