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Leading Pharmaceutical Innovation Trends and Drivers for Growth in the Pharmaceutical Industry

:	Oliver Gassmann, Gerrit Reepmeyer, Maximilian von Zedtwitz
:	Leading Pharmaceutical Innovation Trends and Drivers for Growth in the Pharmaceutical Industry
:	Springer-Verlag
:	9783540776369
:	2
:	CHF 47.50
:

:	Betriebswirtschaft
:	English

:	186
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

Pharmaceutical giants have been doubling their investments in drug development, only to see new drug approvals to remain constant for the past decade. This book investigates and highlights a set of proactive strategies, aimed at generating sustainable competitive advantage for its protagonists based on value-generating business practices. We focus on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R&D, and new forms of internationalisation, such as outside-in innovation in the early phases of R&D.

	Preface for 2nd Edition	5
	Preface for 1st Edition	9
	Contents	13
	I. Innovation: Key to Success in the Pharmaceutical Industry	16
	The Productivity Paradox	16
	The Blockbuster Imperative	19
	High Risks in Drug Development	25
	Strategies for Growth	27
	Differentiation via Clinical Profiles	30
	Entering the Market Quickly	31
	Conclusions	32
	II. The Industry Challenge: Do You Really Want to Be in This Business?	34
	High Complexity of the Industry	34
	How Attractive is the Pharmaceutical Industry?	37
	Force 1: Bargaining Power of Suppliers	39
	Force 2: Bargaining Power of Buyers	40
	Force 3: Risk of Entry from Potential Competitors	41
	Force 4: Threat of Substitute Products	42
	Force 5: Rivalry among Established Companies	43
	Force 6: The Regulators	43
	Conclusions	45
	III. The Science and Technology Challenge: How to Find New Drugs	48
	Rise of the Biotechnology Industry: Boosting Innovation	48
	High-Throughput Screening: Fail Earlier, Succeed Sooner	53
	Combinatorial Chemistry: Cut Experimental Cycle Times	54
	Bioinformatics: More than 100 Gigabytes of Data per Day	55
	Proteomics: Profiting from the Human Genome Project	57
	Genomics: Towards Individualization and Mass Customization	58
	Pharmacogenomics: Create Tailor-made Drugs	60
	Molecular Design: From Experimenting to Analytic Design	62
	Conclusions	63
	IV. The Pipeline Management Challenge: How to Organize Innovation	66
	The Relevance of Pipeline Management	66
	Complexity and Phases of the R	66
	71	66
	The Importance of Project and Portfolio Management	80
	The Disaggregation of the Pharmaceutical Value Chain	83
	Impact of Outsourcing on Pharmaceutical R	83
	86	83
	Rising Importance of R	83
	90	83
	Research Alliances: Accessing Early-stage Innovation	93
	In-licensing: Enhancing the Innovation Pipeline	96
	Co-development: Mutually Benefiting from Joint Resources	98
	Out-licensing: Commercializing Internal Research Results	101
	How to Commercialize a Breakthrough Technology	110
	Conclusions	115
	V. The Internationalization Challenge: Where to Get Access to Innovation	118
	Trends and Drivers of R	118
	118	118
	Primary Locations of Pharmaceutical R	118
	123	118
	New Opportunities for Drug Development in China	126
	Three Principal Problems of Dispersed R	126
	132	126
	Conclusions	136
	VI. Management Answers to Pharmaceutical R	136
	138	136
	Managing R	136
	138	136
	Managing R	136
	140	136
	Managing the Research-to-Development Handover at Roche	142
	Managing Outsourcing Activities at Solvias	145
	Managing Intellectual Property Rights at Bayer	148
	Managing Out-licensing at Novartis	152
	Managing Uncertainty at Roche	159
	Managing Global R	159
	160	159
	Managing a Niche-Market Strategy at Intarcia	166
	Managing Virtual Project Management Pools at Roche	168
	Conclusions	171
	VII. Future Directions and Trends	174
	Bibliography	180
	Index	188
	Glossary	194
	Authors	200