: Frederick Marcus
: Bioinformatics and Systems Biology Collaborative Research and Resources
: Springer-Verlag
: 9783540783534
: 1
: CHF 85.30
:
: Biologie
: English
: 287
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them.

The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.

Preface7
Acknowledgements11
Contents13
Introduction27
Introduction27
Bioinformatics28
Systems Biology33
Research Areas for Analysis39
Collaborative Research40
European Commission Research Projects43
A Practical Guide to Project Websites, Participants, Coordinators, Publications44
Key Sources47
Part I Fundamental Collaborative Research and Computational Biology49
Bioinformatics51
Introduction51
Genome Annotation52
Bioinformatics Tools For Annotation58
Gene Definition/Alternative Transcripts and Splicing63
Gene Regulation and Expression65
Functional Annotation of Proteins68
Post-translation Modification, Membrane and Localisation Prediction70
Protein Complexes, Networks and Pathways73
Encyclopaedia of DNA Elements75
Systems Biology79
Introduction79
Cell Cycle80
P5384
Spindle Formation and Imaging86
Signalling and Control88
Metabolic Regulation93
Circadian Clock96
Multiple Pathway Integration97
Cellular Systems Biology100
Local and Worldwide Scientific Collaboration101
A Major FP7 Initiative in Systems Biology104
Developmental Biology and Ageing111
Introduction111
Plant Development112
Stem Cells and Development116
Mitochondria and Ageing117
Nuclear Receptors and Ageing119
Implementation in the Seventh Framework Programme120
Part II Resources Supporting Bioinformatics and Systems Biology Research123
Databases, Computational Tools and Services125
Introduction125
Major Gateway to Collaborative Research126
Distributed Development of Resources129
Distributed Annotation System131
Database Grid Integration132
Ontologies139
Text Mining140
Systems Biology Toolboxes141
Supporting Infrastructures149
Introduction149
Wet-Laboratory Research Infrastructures150
Research Infrastructures: Future Priorities155
Medical Information Systems158
Knowledge Management Systems158
Education160
Part III Disease-Related Collaborative Research and Computational Biology163
Infectious and Major Diseases165
Introduction165
Viral Pathogens168
Bacterial Pathogens170
Cardiovascular–Pulmonary Diseases and Diabetes173
Neurological Diseases176
Immunology179
Drug Development179
Implementation in the Seventh Framework Programme188
Cancer191
Introduction191
Nature of Cancer and Biology and Genetics of Cells and Organisms194
Tumour Viruses195
Cellular Oncogenes196
Growth Factors and Their Receptors199
Cytoplasmic Signalling Circuitry199
Cell Cycle200
Tumour Suppressor Genes201
p53 and Apoptosis202
Cell Immortalisation, Tumourigenesis and Senescence205
Multistep Tumourigenesis206
Genomic Integrity and the Development of Cancer207
Angiogenesis and Lymphangiogenesis207
Metastasis209
Tumour Immunology and Immunotherapy210
Implementation in the Seventh Framework Programme210
Genetic Variation and Diseases213
Introduction213
Genetic Variation Workshop214
Status of Genetic Variation Research215
Genotype to Phenotype217
Data and Analysis Challenges218
Databases221
Data Generation225
The Way Forward227
Research in the Fifth Framework Programme and the Sixth Framework Programme229
A Major Seventh Framework Programme Initiative in Genetic Variation233
Part IV Science Management, Perspectives and Conclusions239
Science Management241
Introduction241
How To Participate and Develop Proposals246
Evaluation of Proposals254
Project Negotiation257
Operating Project Attributes and its Management261
Contractual and Financial Obligations264
Information Dissemination265
IPR and Exploitation266
Perspectives271
Introduction271
Bioinformatics272
Systems Biology274
Disease277
Seventh Framework Programme279
Longer Term280
Outstanding Results and Conclusions281
Introduction281
Outstanding Resources Created282
Outstanding Scientific Results284
Overall Conclusions287
References289
Index307