: Michael Conn, Claude Kordon, Yves Christen
: P.Michael Conn, Claude Kordon
: Insights into Receptor Function and New Drug Development Targets
: Springer-Verlag
: 9783540344476
: 1
: CHF 85.40
:
: Pharmazie
: English
: 202
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.
Introduction5
Table of Contents7
List of Contributors9
Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE16
Functional Rescue of Misfolded Receptor Mutants38
Obesity-relatedmutations of leptin and melanocortin receptors50
cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management68
Central Neuropeptide Receptors Involved inWater Balance: Application to Apelin94
Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity108
Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?120
Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists132
Mutations in G proteins and G protein-coupled receptors in human endocrine diseases154
Amolecular dissection of the glycoprotein hormone receptors166
Receptor Tyrosine Kinases as Targets for Cancer Therapy Development182
Targets for pituitary tumor therapy194
The endogenous cannabinoid system in the control of food intake and energy balance204
Subject Index216