: John L. Casey
: John L. Casey
: Hepatitis Delta Virus
: Springer-Verlag
: 9783540298021
: 1
: CHF 132.90
:
: Mikrobiologie
: English
: 228
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

Hepatitis delta virus (HDV), which causes severe acute and chronic liver disease, was discovered nearly 30 years ago following the detection of a novel antigen-antibody system in hepatitis B virus carriers. HDV has continued to surprise and fascinate medical science ever since. This volume reviews recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
Preface5
List of Contents8
List of Contributors9
Structure and Replication of Hepatitis Delta Virus RNA10
HDV RNA Replication: Ancient Relic or Primer?34
HDV Ribozymes56
RNA Editing in Hepatitis Delta Virus76
Post-translational Modification of Delta Antigen of Hepatitis D Virus100
The Role of the HBV Envelope Proteins in the HDV Replication Cycle122
Prenylation of HDAg and Antiviral Drug Development142
Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?160
Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection182
Immunology of HDV Infection196
The Woodchuck Model of HDV Infection220
Subject Index235