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Membrane Trafficking in Viral Replication

:	Mark Marsh
:	Mark Marsh
:	Membrane Trafficking in Viral Replication
:	Springer-Verlag
:	9783540267645
:	1
:	CHF 132.90
:

:	Mikrobiologie
:	English

:	259
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

Viruse are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.

	Preface	5
	List of Contents	7
	List of Contributors	8
	Viral Entry	9
	1 Introduction	10
	2 Virus Receptor Binding	12
	3 Virus Internalization	16
	4 Postinternalization Trafficking	21
	5 Membrane Penetration	22
	6 Virus Uncoating	23
	7 Virus Entry as a Target for Antiviral Drugs	24
	8 Perspectives	26
	References	27
	The Many Mechanisms of Viral Membrane Fusion Proteins	33
	1 Introduction	34
	2 Activation of Viral Fusion Proteins	35
	3 Classification of Fusion Proteins Based on Structural Criteria	38
	4 Examples of Fusion Activation Mechanisms	40
	5 Membrane Dynamics During Fusion	48
	6 Membrane-Interacting Regions of Viral Fusion Proteins	49
	7 Rafts in Viral Membrane Fusion	56
	8 Inhibitors of Viral Fusion	57
	9 Perspectives	59
	References	61
	The Role of the Cytoskeleton During Viral Infection	75
	1 Introduction	76
	2 The Cytoskeleton	78
	3 Molecular Motors	82
	4 Experimental Approaches	86
	5 Neurotropic Herpesvirus and Cytoplasmic Transport	90
	6 Retrovirus Entry and Budding	96
	7 Adenovirus Entry and Microtubules	98
	8 Parvovirus Entry and Microtubules	99
	9 Poxviruses Multiple Cargos for Microtubules and Actin Tails	100
	10 Actin Remodelling During Baculovirus Infection	102
	11 Perspectives	103
	References	104
	Nuclear Import in Viral Infections	117
	1 Introduction	118
	2 Nuclear Pore Complexes, Guardians of the Nucleus	119
	3 Soluble Import Receptors Control Nuclear Access	121
	4 Models of Nuclear Pore Complex Translocation	122
	5 Ran-Independent Transport	124
	6 Nuclear Import of Viral Genomes	125
	7 Perspectives	136
	References	137
	Viral RNA Replication in Association with Cellular Membranes	147
	1 Introduction	148
	2 Alphaviruses as Models	149
	3 Alphavirus-Like Superfamily	158
	4 Picornavirus-Like Superfamily	162
	5 Flavivirus-Like Superfamily	167
	6 Nidoviruses	170
	7 Concluding Remarks	171
	References	175
	Synthesis and Quality Control of Viral Membrane Proteins	183
	1 Introduction	184
	2 Protein Biosynthesis	184
	3 Quality Control	193
	4 How Viruses Evolve to Fool the Host	196
	5 Conclusions	199
	References	199
	Receptor Modulation in Viral replication: HIV, HSV, HHV- 8 and HPV: Same Goal, Different Techniques to Interfere with MHC- I Antigen Presentation	207
	1 Introduction	208
	2 Receptor Modulation During Viral Replication: Interference with MHC- I Antigen Presentation	209
	3 Perspectives	219
	References	220
	Trafficking of Viral Membrane Proteins	227
	1 Introduction	227
	2 The Cellular Protein Sorting and Trafficking Machinery	229
	3 Traffic of Viral Envelope Proteins	235
	4 Virus Assembly	248
	5 Conclusions	251
	References	252
	Subject Index	263