| Dedication | 6 |
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| Preface | 7 |
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| Travel Awards | 9 |
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| Contents | 10 |
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| Contributors | 16 |
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| Keynote Lectures | 34 |
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| Curing Blindness with Stem Cells: Hope, Reality, and Challenges | 35 |
| Retinal Degenerations: Planning for the Future | 53 |
| Neuroprotection | 68 |
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| Neurotrophins Induce Neuroprotective Signaling in the Retinal Pigment Epithelial Cell by Activating the Synthesis of the Anti- inflammatory and Anti- apoptotic Neuroprotectin D1 | 69 |
| On the Role of CNTF as a Potential Therapy for Retinal Degeneration: Dr. Jekyll or Mr. Hyde? | 75 |
| Nanoceria Particles Prevent ROI-Induced Blindness | 82 |
| An in-vivo Assay to Identify Compounds Protective Against Light Induced Apoptosis | 89 |
| Role of BCL-XL in Photoreceptor Survival | 96 |
| The Hypoxic Transcriptome of the Retina: Identification of Factors with Potential Neuroprotective Activity | 102 |
| Gene Therapy and Neuroprotection | 113 |
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| Lentiviral Gene Transfer-Mediated Cone Vision Restoration in RPE65 Knockout Mice | 114 |
| In vitro Analysis of Ribozyme-mediated Knockdown of an ADRP Associated Rhodopsin Mutation | 121 |
| Gene Therapy for Mouse Models of ADRP | 131 |
| Development of Viral Vectors with Optimal Transgene Expression for Ocular Gene Therapies | 137 |
| Adeno-Associated Viral Vectors and the Retina | 144 |
| Genetic Supplementation of RDS Alleviates a Loss- of- function Phenotype in C214S Model of Retinitis Pigmentosa | 152 |
| Morphological Aspects Related to Long-term Functional Improvement of the Retina in the 4 Years Following rAAV- mediated Gene Transfer in the RPE65 Null Mutation Dog | 162 |
| Virus-mediated Gene Delivery to Neuronal Progenitors | 170 |
| Animal Models of Retinal Degeneration | 177 |
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| Loss of Visual and Retinal Function in Light- stressed Mice | 178 |
| ERG Responses and Microarray Analysis of Gene Expression in a Multifactorial Murine Model of Age- Related Retinal Degeneration | 186 |
| Oxygen Supply and Retinal Function: Insights from a Transgenic Animal Model | 192 |
| Characterization of Gene Expression Profiles of Normal Canine Retina and Brain Using a Retinal cDNA Microarray | 199 |
| Toward a Higher Fidelity Model of AMD | 205 |
| The Potential of Ambient Light Restriction to Restore Function to the Degenerating P23H- 3 Rat Retina | 213 |
| Molecular Genetics and Candidate Genes | 220 |
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| Mutations in Known Genes Account for 58% of Autosomal Dominant Retinitis Pigmentosa ( adRP) | 221 |
| Genetics of Age-related Macular Degeneration | 228 |
| Retinal Phenotype of an X-Linked Pseudo-usherSyndrome in Association with the G173RMutation in the RPGR Gene | 237 |
| Mutation in the PYK2-Binding Domain of PITPNM3 Causes Autosomal Dominant Cone Dystrophy ( CORD5) in Two Swedish Families | 244 |
| Identification and Characterization of Genes Expressed in Cone Photoreceptors | 250 |
| Clinical and Genetic Characterization of a Chinese Family with CSNB1 | 260 |
| 10q26 Is Associated with Increased Risk of Age- Related Macular Degeneration in the Utah Population | 268 |
| Diagnostic, Clinical, Cytopathological and Physiologic Aspects of Retinal Degeneration | 274 |
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| Carboxyethylpyrrole Adducts, Age-related Macular Degeneration and Neovascularization | 275 |
| A Possible Impaired Signaling Mechanism in Human Retinal Pigment Epithelial Cells from Patients with Macular Degeneration | 282 |
| Expression and Cell Compartmentalizationof EFEMP1, a Protein Associated with Malattia Leventinese | 289 |
| Role of ELOVL4 in Fatty Acid Metabolism | 294 |
| Organization and Molecular Interactions of Retinoschisin in Photoreceptors | 302 |
| Basic Science Underlying Retinal Degeneration | 309 |
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| Proteomics Profiling of the Cone Photoreceptor Cell Line, 661W | 310 |
| .-Secretase Regulates VEGFR-1 Signallingin Vascular Endothelium and RPE | 321 |
| Analysis of the Rate of Disk Membrane Digestion by Cultured RPE Cells | 328 |
| Functional Expression of Cone Cyclic Nucleotide- Gated Channel in Cone Photoreceptor- Derived 661W Cells | 334 |
| Phosphorylation of Caveolin-1 in Bovine Rod Outer Segments in vitro by an Endogenous Tyrosine Kinase | 342 |
| Regulation of Neurotrophin Expression and Activity in the Retina | 349 |
| Involvement of Guanylate Cyclases in Transport of Photoreceptor Peripheral Membrane Proteins | 356 |
| Rod Progenitor Cells in the Mature Zebrafish Retina | 365 |
| avß5 Integrin Receptors at the Apical Surfaceof the RPE: One Receptor, Two Functions | 373 |
| Implantation of Mouse Eyes with a Subretinal Microphotodiode Array | 380 |
| Variation in the Electroretinogram of C57BL/6 Substrains of Mouse | 386 |
| A2E, A Pigment of RPE Lipofuscin, is Generated from the Precursor, A2PE by a Lysosomal Enzyme Activity | 395 |
| Endothelin Receptors: Do They Have a Role in Retinal Degeneration? | 401 |
| CNTF Negatively Regulates the Phototransduction Machinery in Rod Photoreceptors: Implication for Light- Induced Photostasis Plasticity | 408 |
| Index | 418 |
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