| CONTENTS | 5 |
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| INTRODUCTION Bloinformatics: Mystery, Astrology or Service Technology? | 12 |
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| SECTION I Deriving Biological Function of Genome Information with Biomolecular Sequence and Structure Analysis | 22 |
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| CHAPTER 1 Reliable and Specific Protein Function Prediction by Combining Homology with Genomic(s) G)ntext | 23 |
| CHAPTER 2 Clues from Three-Dimensional Structure Analysis and Molecular Modelling: New Insights into Cytochrome P450 Mechanisms and Functions | 40 |
| CHAPTER 3 Prediction of Protein Function: Two Basic Concepts and One Practical Recipe | 49 |
| SECTION II Complementing Biomolecular Sequence Analysis with Text Mining in Scientific Articles | 65 |
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| CHAPTER 4 Extracting Information for Meaningful Function Inference through Text-Mining | 66 |
| CHAPTER 5 Literature and Genome Data Mining for Prioritizing Disease-Associated Genes | 83 |
| SECTION III Mechanistic Predictions from the Analysis of Biomolecular Networks | 91 |
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| CHAPTER 6 Model-Based Inference of Transcriptional Regulatory Mechanisms from DNA Microarray Data | 92 |
| CHAPTER 7 The Predictive Power of Molecular Network Modelling: Case Studies of Predictions widi Subsequent Experimental Verification | 102 |
| SECTION IV Mechanistic Predictions from the Analysis of Biomolecular Sequence Populations: G) nsidering Evolution for Function Prediction | 111 |
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| CHAPTER 8 Theory of Early Molecular Evolution: Predictions and Confirmations | 112 |
| CHAPTER 9 Hitchhiking Mapping: Limitations and Potential for the Identification of Ecologically Important Genes | 122 |
| CHAPTER 10 Understanding the Functional Importance of Human Single Nucleotide Polymorphisms | 131 |
| CHAPTER 11 Correlations between Quantitative Measures of Genome Evolution, Expression and Function | 138 |
| Index | 150 |
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