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Genomics of Disease

:	JP Gustafson, J. Taylor, G. Stacey
:	J.P. Gustafson, J. Tayler, Glyn Stacey
:	Genomics of Disease
:	Springer-Verlag
:	9780387767239
:	1
:	CHF 131.80
:

:	Klinische Fächer
:	English

:	222
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

This title develops from the 24th Stadler symposium. It explores the general theme 'GENOME EXPLOITATION: Data Mining the Genomes'. The idea behind the theme is to discuss and illustrate how scientists are going to characterize and make use of the massive amount of information being accumulated about plant and animal genomes. The book presents a state-of-the-art picture on mining the Genome databases. Its chapters are authored by key stars in the field.

	Acknowledgments	6
	Contents	7
	Contributors	9
	Roles of Plant Hormones in Plant Resistance and Susceptibility to Pathogens	17
	1 Introduction	17
	2 Flg22 Triggers Auxin-Signaling Repression by Inducing a Specific miRNA	18
	3 Does Auxin Play a Role in Bacterial Pathogenenity?	21
	4 Flg22 Triggers Growth Inhibition of Arabidopsis Seedlings	22
	5 Role of DELLA Proteins in Plant Disease Resistance and Susceptibility	23
	6 Are DELLA Proteins Integrators of Plant Defense Pathways?	24
	References	25
	Canine Genetics Facilitates Understanding of Human Biology	27
	1 Introduction to Dogs and Breeds	27
	2 Mapping Disease Genes in Dogs	28
	3 Canine Breed Relationships	31
	4 Advances in Canine Genomics	32
	5 Mapping Genes for Morphology in the Dog	35
	6 Summary and Future Aims	36
	References	37
	Xanthomonas oryzae pv. oryzae AvrXA21 Activity Is Dependent on a Type One Secretion System, Is Regulated by a Two- Component Regulatory System that Responds to Cell Population Density, and Is Conserved in Other Xanthomonas spp.	41
	1 Detection of Pathogens by Plants and Animal Hosts	42
	2 The PRR XA21 Represents a Large Class of Kinases Predicted to Be Involved in Innate Immunity	44
	3 AVRXA21 Activity Requires a Type One Secretion System	44
	4 The AVRXA21 Pathogen-Associated Molecule Is Conserved in Xanthomonas campestris pv. campestris	47
	5 Cell Density Dependent Expression of Rax Genes	48
	6 Perspective	50
	References	53
	Unraveling the Genetic Mysteries of the Cat: New Discoveries in Feline- Inherited Diseases and Traits	57
	1 Cat Phenotypes	57
	2 Cat Diseases	60
	3 Feline Genetic Resources	63
	4 Reproductive Technologies	64
	5 Future of Cat Genetics	65
	References	66
	APPENDIX: Table references	70
	Variation in Chicken Gene Structure and Expression Associated with Food-Safety Pathogen Resistance: Integrated Approaches to Salmonella Resistance	73
	1 Rationale and Strategies for Uncovering Genetic Resistance to Food- Safety Pathogens in Poultry	73
	2 Genetic Control of Salmonella Resistance in Poultry	77
	3 Conclusions	79
	References	80
	Functional Genomics and Bioinformatics of the Phytophthora sojae Soybean Interaction	83
	1 Introduction	83
	2 Sequencing of Oomycete Genomes	85
	3 Effector Genes in Oomycete Genomes	86
	4 Counter-Play of Plant and Pathogen Genes During Phytophthora Infection of Soybean	89
	References	92
	Canine SINEs and Their Effects on Phenotypes of the Domestic Dog	95
	1 Short Interspersed Elements	95
	2 Merle Patterning	96
	3 A-Tails Are Important	100
	4 Summary	101
	References	101
	Ovine Disease Resistance: Integrating Comparative and Functional Genomics Approaches in a Genome Information- Poor Species	104
	1 Introduction	105
	2 Tools Used to Obtain Candidate Genes 2.1 Resource Flocks for QTL Analysis and Mapping	107
	2.2 Integrated Maps, Comparative Mapping and Meta-analysis	107
	2.3 Association Studies, SNP Chips and LD Mapping	109
	2.4 Microarrays, SELDI-TOF MS and Other High Density Genomic or Proteomic Functional Tools	113
	2.5 Positional Functional Integration	114
	3 An Example: Mapping Genes for Ruminant Fasciolosis	115
	3.1 Resistance to Fasciola	116
	3.2 The Resource Flock for Mapping Fasciolosis Resistance	116
	3.3 Linkage and QTL Analysis for Fasciolosis	117
	3.4 Mapping Fasciolosis QTL in Cattle and Buffalo	120
	3.5 Immunological Characterisation for Functional Positional Integration	120
	3.6 High Density Proteomic and Genomic Functional Screening	122
	3.7 Future Studies and Potential Applications	122
	References	124
	Integrating Genomics to Understand the Marek’s Disease Virus – Chicken Host – Pathogen Interaction	129
	1 Introduction	129
	2 Marek’s Disease	130
	2.1 MD as a Model	131
	2.2 Genetic Resistance	131
	3 Integrating Genomics, Version 1.0 (Before the Genome Sequence)	132
	3.1 Genome-Wide QTL Scans	133
	3.2 Gene Profiling	134
	3.3 VirusÒHost ProteinÒProtein Interaction Screens	134
	4 Integrating Genomics, Version 2.0 (After the Genome Sequence)	136
	4.1 Genome-Wide QTL Scans	136
	4.2 Gene Profiling	137
	4.3 VirusÒHost ProteinÒProtein Interaction Screens	137
	5 Some Final Thoughts	138
	References	138
	Combining Genomic Tools to Dissect Multifactorial Virulence in Pseudomonas aeruginosa	141
	1 Introduction	141
	2 Background 2.1 Pseudomonas aeruginosa is an Opportunistic Human Pathogen	142
	2.2 The Model Host System for Studying Pathogenesis	143
	3 Genomic Sequence of P. aeruginosa, Strain PA14 3.1 Comparative Alignments with Strain PAO1	145
	3.2 Annotation of the PA14 Genome	148
	4 Relationship Between Genomic Content and Virulence 4.1