| Cell Stress Proteins | 3 |
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| Contents | 6 |
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| Foreword | 9 |
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| Acknowledgement | 10 |
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| List of Contributors | 11 |
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| Introduction: Heat Shock Proteins— From Drosophila Stress Proteins to Mediators of Human Disease | 14 |
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| Stress Response and Molecular Chaperones | 18 |
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| Biology of the Heat Shock Response and Stress Conditioning | 19 |
| Bacterial Stress Sensors | 48 |
| Unfolded Protein Response: Contributions to Development and Disease | 69 |
| Molecular Mechanisms of Stress Protein Expression | 101 |
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| Genetic Models of HSF Function | 102 |
| HSF1 and HSP Gene Regulation | 133 |
| Cellular Stress Proteins | 151 |
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| Small Heat Shock Proteins in Physiological and Stress- Related Processes | 152 |
| Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy | 187 |
| Molecular Chaperones and Protein Folding | 215 |
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| Regulation of Hsp70 Function: Hsp40 Co- Chaperones and Nucleotide Exchange Factors | 216 |
| Protein Disassembly by Hsp40–Hsp70 | 235 |
| Mammalian HSP40/DnaJ Chaperone Proteins in Cytosol | 262 |
| Role of Molecular Chaperones in Cell Regulation | 285 |
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| FKBP Co-Chaperones in Steroid Receptor Complexes | 286 |
| Up and Down | 318 |
| Role of Cdc37 in Protein Kinase Folding | 331 |
| Intracellular and Extracellular Stress Proteins in Human Disease | 343 |
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| Targeting Hsp90 in Cancer and Neurodegenerative Disease | 344 |
| gp96 and Tumor Immunity | 367 |
| Immunoregulatory Activities of Extracellular Stress Proteins | 380 |
| Heat Shock Proteins and Neurodegenerative Diseases | 399 |
| Heat Shock Proteins in the Progression of Cancer | 425 |
| Index | 454 |
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| Color Plate I | 463 |
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| Color Plate II | 464 |
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