| Preface | 6 |
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| Contents | 8 |
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| Contributors | 10 |
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| Adrenal Embryology and Pathology | 12 |
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| Introduction | 12 |
| Embryology and Developmental Disorders of the Adrenal Glands | 12 |
| Gross and Microscopic Anatomy of the Adrenal Glands | 14 |
| Hyperplastic Disorders | 16 |
| Cortical Hyperplasia | 16 |
| Pituitary/Hypothalamic-based Hyperplasia (Cushing’s Disease) | 17 |
| Cortical Hyperplasia Associated with Ectopic Production of Adrenocorticotropic Hormone or Corticotropin-releasing Hormone | 17 |
| Cortical Hyperplasia Associated with Hyperaldosteronism | 18 |
| Macronodular Hyperplasia (Massive Macronodular Adrenal Cortical Disease) | 18 |
| Primary Pigmented Nodular Adrenocortical Disease-Microadenomatous Hyperplasia of the Adrenal | 18 |
| Other Types of Adrenal Hyperplasia | 19 |
| Adrenal Neoplasms | 19 |
| Cortical Adenomas | 20 |
| Nonfunctional Cortical Adenomas and Cortical Nodules | 20 |
| Cushing’s Syndrome | 20 |
| Conn’s Syndrome | 21 |
| Adrenogenital Syndromes (Sex Steroid Overproduction) | 22 |
| Oncocytic Adenoma (Oncocytoma) | 22 |
| Cortical Carcinoma | 23 |
| Neuroblastic Tumors | 26 |
| Pheochromocytoma | 30 |
| Other Adrenal Mass Lesions | 34 |
| Metastatic Malignancies and Malignant Lymphoma | 34 |
| Cysts and Pseudocysts | 35 |
| Myelolipoma | 36 |
| Connective Tissue Tumors | 37 |
| Other Tumors | 37 |
| Needle Biopsy of Adrenal Masses | 37 |
| Metabolic Disorders | 39 |
| Storage Diseases | 39 |
| Congenital Adrenal Hyperplasia | 39 |
| Hypofunctional States | 40 |
| Primary Hypofunction | 40 |
| Autoimmune Adrenalitis | 40 |
| Infectious Disorders | 40 |
| Amyloidosis | 41 |
| Adrenal Hemorrhage | 41 |
| Secondary Hypofunction | 41 |
| References | 41 |
| Adrenocortical Dysfunction | 45 |
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| Normal Physiology and Regulation of Adrenocortical Function | 46 |
| Biosynthesis of Adrenal Steroids | 46 |
| Steroid Transport | 47 |
| Steroid Metabolism and Excretion | 47 |
| Glucocorticoids | 47 |
| Mineralocorticoids | 47 |
| Adrenal Androgen | 47 |
| Regulation of Hypothalamic-Pituitary-Adrenal Axis | 47 |
| Factors Controlling the Release of ACTH | 47 |
| Physiologic Actions of Glucocorticoids (GC) | 48 |
| Molecular Mechanisms of Cortisol Action | 49 |
| Regulation of Renin-Angiotensin-Aldosterone Axis | 49 |
| Physiology of Renin-Angiotensin | 49 |
| Regulation of Renin Secretion | 49 |
| Physiological Actions of Aldosterone | 50 |
| Regulation of Aldosterone Secretion | 51 |
| Adrenal Androgen Physiology | 51 |
| Laboratory Evaluation of Adrenocortical Function | 51 |
| Cushing’s Syndrome | 51 |
| ACTH-Dependent Causes | 51 |
| Cushing’s Disease | 51 |
| Ectopic ACTH Syndrome | 52 |
| Other Causes | 53 |
| ACTH-Independent Causes | 53 |
| Other Etiologies | 53 |
| Clinical Features of Cushing’s Syndrome | 54 |
| Diagnosis | 54 |
| Investigations to Determine the Etiology of Cushing’s Syndrome | 54 |
| Radiological Evaluation of Cushing’s Syndrome | 55 |
| Differential Diagnosis | 55 |
| Pseudo-Cushing’s Syndrome | 55 |
| Management | 55 |
| ACTH Dependent Causes | 55 |
| Ectopic ACTH Syndrome | 55 |
| Adrenal Etiologies | 56 |
| Medical Therapies for Cushing’s Syndrome | 56 |
| Mineralocorticoid Excess | 57 |
| Hyperaldosteronism | 57 |
| Primary Hyperaldosteronism | 57 |
| Etiology | 57 |
| Clinical Features | 58 |
| Aldosterone and Cardiovascular Damage | 58 |
| Diagnosis | 58 |
| Differential Diagnosis | 59 |
| Management | 59 |
| Glucocorticoid-Remediable Aldosteronism | 59 |
| Secondary Hyperaldosteronism | 60 |
| Other Causes of Increased Mineralocorticoid Action | 60 |
| Hypoaldosteronism with Low Plasma Renin Activity | 60 |
| Apparent Mineralocorticoid Excess | 60 |
| Liddle’s Syndrome | 60 |
| Hyperaldosteronism with High Plasma Renin Activity | 60 |
| Bartter’s Syndrome | 60 |
| Gitelman’s Syndrome | 60 |
| Primary Adrenal Insufficiency
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