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Atlas of Psoriatic Arthritis

:	P. J. Mease, P. S. Helliwell
:	Philip J. Mease, Philip S. Helliwell
:	Atlas of Psoriatic Arthritis
:	Springer-Verlag
:	9781846288975
:	1
:	CHF 47.50
:

:	Klinische Fächer
:	English

:	118
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

Psoriatic arthritis (PsA) is a form of arthritic joint disease associated with the chronic skin scaling and fingernail changes seen in psoriasis. Patients with PsA have a reduced quality of life. This comprehensive visual reference contains over 150 images from a wide gamut of variations of the disease, as well as charts and tables detailing the most up-to-date information on patient susceptibility, incidence, and symptoms.

Philip J. Mease, MD, is a clinical professor at the University of Washington School of Medicine in Seattle, where he has also been chief resident and fellow in rheumatology, and is chief of rheumatology clinical research at the Swedish Hospital Medical Center. He is highly involved in clinical trials of new therapies for a number of rheumatic disease conditions, (including rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis, lupus, fibromyalgia and osteoporosis,) and is a founding organizer of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis.) Publications include numerous articles and book contributions. Philip Mease also sits on review boards for The Journal of Rheumatology, Arthritis& Rheumatism, and The Annals of the Rheumatic Diseases and has received the Medical Communicator Award of the American College of Rheumatology.

Dr Mease chairs / co-chairs three working groups of OMERACT (Outcome Measures in Rheumatology): psoriatic arthritis, fibromyalgia and single joint assessment. He is also on the medical advisory boards of pharmaceutical and biotechnology companies, the Lupus Foundation, the Psoriasis Foundation, and the Northwest Arthritis& Osteoporosis Institute. With a strong interest in education, he is also a part of the speakers' bureaus of the Arthritis Foundation, Lupus Foundation, National Psoriasis Foundation, Wyeth Ayerst, SmithKline Beecham, Genelab Technologies, Proctor& Gamble - to name but a few.

Philip S. Helliwell, BM, BCh, is currently senior lecturer in rheumatology at the University of Leeds, Academic Unit of Musculoskeletal& Rehabilitation Medicine. His interests include chronic pain, disability, and communication. He has written about the Moll and Wright classification criteria for diagnosing PsA, making the case for retaining at least the two subgroups of peripheral and axial disease and splitting the peripheral disease into oligo- and polyarthritis.

	Contents	5
	Contributors	7
	Introduction	9
	References	10
	Epidemiology	11
	Incidence and prevalence data for PsA in published studies	12
	Prevalence of PsA among patients with psoriasis	13
	Predominantly DIP joint involvement in PsA	13
	Oligoarthritis in patients with PsA	14
	Symmetric polyarthritis in PsA	14
	Arthritis mutilans in PsA	15
	Spondyloarthritis in PsA	15
	Change in patterns of PsA in 664 patients in an inception cohort	16
	Dactylitis in fingers and toes in PsA	16
	Photograph and radiograph of enthesitis in PsA	17
	Adjusted mean SF-36 health survey scores for PsA sample and UK and USA general populations	17
	Predictive factors for mortality in PsA	18
	Factors associated with remission in PsA	18
	HLA gene complex - chromosome 6	19
	HLA antigens and disease progression in PsA Genetic basis of psoriasis: genome scans	20
	References	21
	Etiology and Pathophysiology	25
	Etiology	25
	Genetic factors	25
	Environmental factors	25
	Pathogenesis	26
	Synovial membrane characteristics	26
	Enthesis	26
	Mechanisms of joint destruction	26
	Environmental factors in the pathogenesis of RA	27
	Histology of psoriatic plaque Vascular morphology in psoriatic and rheumatoid synovium	27
	hybridization for VEGF and Ang-2 mRNA in patients with early PsA and RA	28
	Synovial membrane characteristics – features of psoriatic synovium	28
	MRI showing acute enthesitis	29
	Undifferentiated SpA at baseline and 6 months after treatment	29
	Distal digit osteolysis in PsA	30
	Osteoclasts are prominent in the psoriatic joint Bone and cartilage destruction in PsA	30
	Osteoclastogenesis pathway	31
	Schematic model of osteolysis in the psoriatic joint	31
	References	32
	Clinical Evaluation	35
	PsA clinical subgroups of Moll and Wright	36
	DIP joint inflammation	37
	Asymmetric oligoarthritis	37
	Classic ankylosing spondylitis	38
	Symmetric polyarthritis	38
	Distinctive mutilation in PsA	39
	Dactylitis in the hand and foot	39
	Entheseal sites in PsA	40
	SAPHO syndrome – palmoplantar pustulosis	40
	SAPHO syndrome – abnormal radioisotope uptake in psoriasis vulgaris Eye disease in PsA	41
	Pitting edema in PsA Relationship between joint symmetry and number of joints in PsA	41
	Juvenile PsA	42
	HIV and PsA	42
	Clinical syndromes that suggest PsA	42
	General diagnostic principles for PsA Flexural psoriasis	43
	Left and right hand of a 67-year-old male at first presentation	44
	Inflammatory articular disease (joint, spine, or entheseal)	44
	Screening questions for arthritis	45
	Diagnostic pointers to distinguish PsA from RA	46
	References	47
	Distinguishing PsA from other SpAs	47
	Imaging	49
	Plain radiographs of patients with arthritis mutilans	50
	Plain radiograph of ‘whittling’ in PsA	50
	Plain radiograph of characteristic changes in finger in chronic PsA – classic periostitis	51
	Inflammatory polyarthritis in chronic PsA	51
	Multiple peri-articular bone erosions in PsA patient receiving combination therapy	52
	PsA with rheumatoid-like features – ulnar deviation of the MCP joints	52
	PsA with rheumatoid-like features – fibular deviation of the toes	53
	Monoarthritis of the right wrist in patient with PsA	53
	Syndesmophytes in PsA	54
	Enthesophytes in PsA	54
	Ultrasonographs showing capsular edema in PsA	55
	Ultrasonography of patellar tendon enthesitis in PsA	55
	Ultrasonographs of plantar fasciitis and patellar tendonitis	55
	Ultrasonography and MRI of plantar faciitis in PsA	56
	MRI of the hands in PsA – capsular-based edema	56
	Use of MRI in early PsA	57
	MRI of knee of HLA-B27-positive patient with PsA	57
	MRI of patient with SAPHO syndrome	58
	Scintigraphy and MRI of patient with SAPHO syndrome	58
	Imaging of sacroiliac joints of patient with HLA-B27-positive PsA	59
	CT scan of pelvis of PsA patient showing sacroiliitis	59
	References	60
	Skin and Psoriasis	63
	Pathophysiology	63
	The Psoriasis Phenotype	63
	MHC and non-MHC psoriasis loci	64
	Histopathology of psoriasis	65
	Examples of plaque-type psoriasis	65
	Examples of plaque-type psoriasis	66
	Examples of partially cleared psoriasis	66
	Guttate psoriasis	67
	Psoriatic flare	67
	Distribution of psoriasis	67
	Palmoplantar psoriasis	68
	Pustular psoriasis	69
	Erythrodermic psoriasis	69
	Psoriatic nail disease	70
	References	70
	Juvenile Psoriatic Arthritis	73
	Introduction	73
	Clinical Features of Juvenile Psoriatic Arthritis	73
	Dactylitis	73
	Psoriasis	73
	Uveitis	73
	Growth Disturbances	74
	Other Systemic Manifestations of JPsA	74
	Imaging	74
	Treatment	74
	Outcome and Prognosis	74
	Differential diagnosis of musculoskeletal disorders in children	75
	Definition of JIA