: P. Michael Conn, Vivian A. Fonseca
: Vivian Fonseca
: Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads
: Humana Press
: 9781597451413
: 1
: CHF 94.70
:
: Klinische Fächer
: English
: 261
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

Over the past few decades, cardiovascular disease and diabetes have emerged as major public health problems, both as distinct clinical entities and as comorbid conditions. As a result, the fields of vascular biology and endocrinology are working more closely now than ever before. With chapters by renowned experts,Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads emphasizes the considerable physiological interrelationships and clinical correlations between the specialties of cardiovascular medicine and endocrinology.

Offering a wealth of information,Cardiovascula Endocrinology: Shared Pathways and Clinical Crossroadsprovides a range of insights, including a novel view of the hormonal regulation of the vascular system and the disruption of the nitric oxide signaling system. It also addresses the role of fatty acids and cytokines in the development of this problem. Importantly, this unique title also provides a state-of-the-art update on the importance of other hormones such as thyroid hormone and steroids, as well as the pathophysiology of cardiovascular disease and controversies surrounding the use of hormone replacement therapy.

In all,Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads is a first-of-its-kind title that discusses and summarizes important clinical topics in cardiology and endocrinology. It offers clinicians and researchers an important resource for navigating the increasingly interrelated pathways of cardiovascular and endocrinologic disorders. The authors discuss a range of important issues from epidemiology to bench research to translation of this research to clinical practice.

Preface6
Contents8
Contributors10
Color Plates12
Hormonal Regulation of the Vascular System: An Overview13
INTRODUCTION13
ESTROGEN18
PROGESTERONE19
ANDROGENS19
CONCLUSION21
REFERENCES21
I DIABETES AND CARDIOVASCULAR DISEASE29
Epidemiology and Prevention of Cardiovascular Disease in Diabetes31
PREVALENCE OF DIABETES32
IMPACT OF DIABETES ON HEALTH AND HEALTHCARE COSTS32
DIABETES AS A RISK FACTOR FOR CORONARY ARTERY DISEASE33
OUTCOME AMONG DIABETES PATIENTS WITH CORONARY ARTERY DISEASE34
DIABETES AS A RISK FACTOR FOR HEART FAILURE34
OUTCOMES AMONG DIABETES PATIENTS WITH HEART FAILURE34
SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES – BLOOD PRESSURE CONTROL34
SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES – LIPID CONTROL37
SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES – GLYCEMIC CONTROL40
SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES – SMOKING CESSATION41
SUMMARY42
ACKNOWLEDGMENTS42
REFERENCES42
Disruption of the Nitric Oxide Signaling System in Diabetes47
INTRODUCTION48
VASCULAR ENDOTHELIUM49
NO SYNTHASE/SOLUBLE GUANYLATE CYCLASE/CYCLIC GMP- DEPENDENT PATHWAY49
ENDOTHELIAL DYSFUNCTION50
INFLUENCES OF DIABETES ON THE VASCULAR WALL50
NITROSATIVE STRESS STATE56
MITOCHONDRIA57
CONCLUSION60
REFERENCES61
Free Fatty Acids, A Major Link Between Obesity, Insulin Resistance, Inflammation, and Atherosclerotic Vascular Disease73
INTRODUCTION74
FFA AND INSULIN RESISTANCE75
MECHANISM FOR FFA-INDUCED INSULIN RESISTANCE76
FFA AND INFLAMMATION77
BLOOD COAGULATION/FIBRINOLYSIS78
FFA AND LIPOPROTEINS79
ACKNOWLEDGMENTS80
REFERENCES80
The Anti-Inflammatory and Antiatherogenic Effects of Insulin83
ANTI-INFLAMMATORY EFFECTS OF INSULIN84
ANTIATHEROGENIC EFFECT OF INSULIN86
PROINFLAMMATORY EFFECTS OF GLUCOSE AND OTHER MACRONUTRIENTS86
CLINICAL IMPLICATIONS87
REFERENCES89
Insulin Sensitizers and Cardiovascular Disease93
INTRODUCTION94
EFFECTS OF INSULIN SENSITIZERS ON LIPID METABOLISM95
INSULIN SENSITIZERS AND HYPERTENSION95
ROLE OF INSULIN SENSITIZERS IN ENDOTHELIAL FUNCTION AND VASCULAR REACTIVITY96
INSULIN SENSITIZERS AND VASCULAR WALL ABNORMALITIES98
INSULIN SENSITIZERS AND FIBRINOLYSIS AND COAGULATION98
INSULIN SENSITIZERS AND ALBUMINURIA99
EFFECT OF INSULIN SENSITIZERS ON CONGESTIVE HEART FAILURE, LEFT VENTRICULAR MASS, AND TYPE 2 DIABETES99
OUTCOME STUDIES FOR PREVENTION OF MACROVASCULAR COMPLICATIONS IN TYPE 2 DM100
ONGOING STUDIES102
CONCLUSION103
ACKNOWLEDGMENTS103
REFERENCES103
Screening for Cardiovascular Disease in Symptomatic and Asymptomatic Patients with Diabetes Mellitus109
CORONARY ARTERY DISEASE IN DIABETES MELLITUS110
STRESS ECHOCARDIOGRAPHY110
NUCLEAR STRESS MYOCARDIAL PERFUSION IMAGING114
COMPUTED TOMOGRAPHY FOR CORONARY ARTERY CALCIUM SCREENING120
CURRENT RECOMMENDATIONS124
CONCLUSIONS125
REFERENCES126
II ENDOCRINE HYPERTENSION AND CARDIOVASCULAR EVENTS131
Renin-Angiotensin System133
RENIN-ANGIOTENSIN SYSTEM134
THE CIRCULATING AND TISSUE RAS135
RENIN135
ANGIOTENSINOGEN136
ENZYMES IN THE RAS137
ANGIOTENSIN PEPTIDES: THEIR ACTION, FORMATION, AND DEGRADATION ( FIG. 1)141
ANGIOTENSIN RECEPTORS142
TISSUE RAS144