| Preface to the 2nd edition | 6 |
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| Preface to the 1st edition | 8 |
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| Table of Contents | 10 |
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| List of Contributors | 12 |
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| 1 Sudden Death in Heart Failure: Risk Stratification and Treatment Strategies --- M. ZECCHIN, G.VITRELLA AND G. SINAGRA | 13 |
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| Definitions and Epidemiology | 13 |
| Mechanisms | 15 |
| Identifying Patients at Risk | 16 |
| Prevention | 17 |
| Pharmacologic Prevention | 18 |
| ß-blockers | 19 |
| Antiarrhythmic Drugs | 20 |
| Internal Cardioverter-Defibrillator (ICD) | 21 |
| ICD for Primary Prevention | 22 |
| ICD for Secondary Prevention | 23 |
| Role of Myocardial Revascularization for the Prevention of Sudden Death | 24 |
| Conclusions | 25 |
| References | 25 |
| 2 Etiology and Pathophysiology of Heart Failure --- P. FOËX AND G.HOWARD-ALPE | 33 |
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| Introduction | 33 |
| Etiology of Heart Failure | 33 |
| Cardiomyopathies | 34 |
| Myocardial Overload | 35 |
| Myocardial Ischemia and Infarction | 35 |
| Pathophysiology of Heart Failure | 35 |
| Systolic Dysfunction | 38 |
| Diastolic Dysfunction | 39 |
| Left Ventricular Inflow | 40 |
| Pulmonary Venous Flow | 42 |
| Right Ventricular Dysfunction | 43 |
| Cardiac Failure and Perioperative Risk | 47 |
| Conclusion | 48 |
| References | 48 |
| 3 Cardiac Protection for Noncardiac Surgery --- P. FOËX AND G.HOWARD-ALPE | 53 |
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| Introduction | 53 |
| Mechanisms of Myocardial Ischemia and Its Complications | 54 |
| Identification of High-Risk Patients | 55 |
| Coronary Revascularization or Pharmacological Prophylaxis? | 57 |
| Prophylaxis Based on Hemodynamic Stabilization | 57 |
| Nitrates | 58 |
| Calcium Channel Blockers | 58 |
| a2-Adrenoceptor Agonists | 58 |
| Adenosine Modulators | 58 |
| KATP Channel Openers | 59 |
| Na+/H+ Exchanger Blockers | 59 |
| ACE Inhibitors | 59 |
| ß-Adrenoreceptor Blockers | 60 |
| Statins | 64 |
| Aspirin | 66 |
| Conclusion | 66 |
| References | 67 |
| 4 Hypertensive Urgencies and Emergencies --- J. L.ATLEE | 73 |
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| Hypertension: Perspectives and Definitions | 73 |
| Perspectives | 73 |
| Definition | 73 |
| Primary vs. Secondary Hypertension | 75 |
| Complications of Hypertension | 75 |
| Hypertensive Crises: Urgencies and Emergencies | 78 |
| Definitions | 78 |
| Incidence and Causes | 79 |
| Pathophysiology | 79 |
| Manifestations and Course | 80 |
| Differential Diagnosis | 81 |
| Therapy: Perioperative Settings | 82 |
| References | 86 |
| 5 Heart Failure, Atrial Fibrillation, and Diabetes Mellitus --- A.ALEKSOVA,A.PERKAN AND G.SINAGRA | 89 |
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| Epidemiology of Heart Failure in Patients with Diabetes Mellitus | 89 |
| Prevalence of Atrial Fibrillation in Patients with Diabetes Mellitus | 90 |
| Mechanism of Atrial Fibrillation Development in Patients with Diabetes Mellitus and Heart Failure | 91 |
| Management of Diabetic Patients with Heart Failure and Atrial Fibrillation | 92 |
| Beta-Blockers | 92 |
| Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers | 93 |
| Statins | 95 |
| Metabolic Control | 95 |
| Anticoagulant Therapy | 96 |
| Conclusions | 96 |
| References | 96 |
| 6 Circulatory Failure: Bedside Functional Hemodynamic Monitoring --- C. SORBARA, S. ROMAGNOLI,A.ROSSI AND S.M. ROMANO | 101 |
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| Introduction | 101 |
| Preload Reserve: Preload and Preload Responsiveness | 102 |
| Preload Responsiveness and Dynamic Parameters | 104 |
| Limitations and Pitfalls | 108 |
| Afterload Reserve and Dynamic Parameters | 109 |
| Cardiac Reserve: Contractility and Efficiency | 111 |
| Cardiac Power | 111 |
| Cardiac Cycle Efficiency (CCE) | 114 |
| Conclusions | 117 |
| References | 118 |
| 7 Perioperative Cardiac Risk Stratification --- F.R.B.G.GALAS, L.A. HAJJAR AND J.O.C.AULER JR. | 121 |
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| Introduction | 121 |
| Clinical Predictors of Risk | 122 |
| Type of Surgery | 122 |
| Patient’s Functional Status | 124 |
| Comorbid Diseases and Risk Factors | 125 |
| Cardiac Risk Indices and Algorithms in Noncardiac Surgery | 125 |
| Supplemental Preoperative Evaluation | 131 |
| Resting Left Ventricular Function | 133 |
| Assessment of Risk for CAD and Functional Capacity | 134 |
| Assessing and Reducing the Cardiac Risk of Noncardiac Surgery: Evidence Base | 137 |
| Preoperative Clinical Assessment: Developing Initial Estimates of Risk | 137 |
| Use of Exercise Capacity as a Preoperative Screening Tool | 138 |
| Valvular Heart Disease | 138 |
| Heart Failure | 139 |
| Systemic Hypertension | 140 |
| Pulmonary Hypertension and Congenital Heart Disease | 140 |
| Refining Initial Risk Estimates: Risk Stratification Tests | 141 |
| Approaches to Reducing Risk | 142 |
| Risk Stratification in Cardiac Surgery | 142 |
| Implications of Risk Assessment Strategies and Costs | 144 |
| References | 144 |
| 8 Hemodynamic Monitoring in Patients with Acute Heart Failure --- J.-L.VINCENT AND R.HOLSTEN | 147 |
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| Introduction | 147 |
| Hemodynamic Monitoring in Acute Heart Failure | 148 |
| Invasive Monitoring | 148 |
| Less-Invasive Hemodynamic Monitoring | 151 |
| Integration into Clinical Practice | 153 |
| References | 154 |
| 9 Electrocardiography of Heart Failure: Features and Arrhythmias --- J. L.ATLEE | 157 |
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| Heart Failure: Definitions and Perspectives | 157 |
| Electrocardiographic Features of Heart Failure | 159 |
| Left and Right At
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