Cell Therapy, Stem Cells and Brain Repair
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Cyndy D. Davis, Paul R. Sanberg
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Cell Therapy, Stem Cells and Brain Repair
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Humana Press
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9781597451475
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1
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CHF 198.60
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Nichtklinische Fächer
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English
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392
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Wasserzeichen/DRM
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PC/MAC/eReader/Tablet
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PDF
As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson's disease, Huntington's disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body's own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.
Preface
6
Contents
12
Contributors
14
Color Plates
17
Current Views of the Embryonic and Neural Stem Cell
18
Developing Novel Cell Sources for Transplantation in Parkinson’s Disease
48
Neural Transplantation in the Nonhuman Primate Model of Parkinson’s Disease
77
Cell-Based Therapy for Huntington’s Disease
99
Use of Bone Marrow Stem Cells as Therapy for Behavioral Deficits in Rodent Models of Huntington’s Disease
132
Human Neuroteratocarcinoma Cells as a Neural Progenitor Graft Source for Cell Transplantation in Stroke
154
Therapeutic Applications of Bone Marrow – Derived Stem Cells in Neurologic Injury and Disease
178
Cell Therapy for Models of Pain and Traumatic Brain Injury
213
The Use of Sertoli Cells in Neural Transplantation
258
The Choroid Plexus
277
Progress and Challenges in Immunoisolation for CNS Cell Therapy
302
Evidence-Based Methodology for Advancing Neural Reconstruction
339
Hematopoietic Cell Therapy for Brain Repair
354
Stem Cells and Regenerative Medicine
376
