: Salvatore J. Enna, Hanns Möhler
: The GABA Receptors
: Humana Press
: 9781597454650
: 3
: CHF 198.60
:
: Nichtklinische Fächer
: English
: 325
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

Preface6
Contents7
Contributors9
1 The GABA Receptors11
2 Functional Relevance of GABAA-Receptor Subtypes32
3 Trafficking of Postsynaptic GABAA Receptors by Receptor-Associated Proteins49
4 Subunit Composition and Structure of GABAA-Receptor Subtypes76
5 Differential Activation of GABAA-Receptor Subtypes94
6 GABAA-Receptor Mutations Associated With Idiopathic Generalized Epilepsies and Febrile Seizures118
7 Abuse and Dependence Liability of GABAA-Receptor Modulators150
8 Mechanisms of GABAA and GABAB Receptor Gene Regulation and Cell Surface Expression176
9 Chemistry of GABAB Modulators246
10 The Unusual Functioning of the GABAB-Receptor Heterodimer259
11 Characteristics of GABAB Receptor Mutant Mice278
12 GABAB Receptor as a Potential Therapeutic Target293
Index317