: B.L. Rapoport, G. Troncone, F. Schmitt, S. Nayler
: Fast Facts: Comprehensive Genomic Profiling Making precision medicine possible
: Karger
: 9783318068191
: 1
: CHF 0.50
:
: Nichtklinische Fächer
: English
: 108
: DRM
: PC/MAC/eReader/Tablet
: ePUB/PDF
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge - or memory - of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents:• Genetic mutations and biomarkers• Understanding next-generation sequencing• Elements of comprehensive genomic profiles• Role in precision oncology• Predictive and prognostic biomarkers• Overcoming barriers to genotype-directed therapy