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The Chemokine Receptors

:	Jeffrey K. Harrison, Nicholas W. Lukacs
:	The Chemokine Receptors
:	Humana Press
:	9781597450201
:	1
:	CHF 201.00
:

:	Nichtklinische Fächer
:	English

:	403
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lymphocyte trafficking; and Chemokine Receptors in diseases such as AIDs and lung cancer. In particular the book contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines.

	Preface	6
	Contents	7
	Contributors	9
	Color Plate	13
	1 The Birth and Maturation of Chemokines and Their Receptors (Nicholas W. Lukacs and Jeffrey K. Harrison)	14
	1.1. Birth of Chemotactic Cytokines, or Chemokines	14
	1.2. Identification of Chemokine Receptors as G Protein – Coupled Receptors	17
	1.3. Chemokine Receptors: Beyond Migration of Leukocytes	18
	1.4. The Future of Chemokine Receptors: Are They Valid Drug Targets?	19
	References	20
	2 The Structural Biology of Chemokines (Elias Lolis and James W. Murphy)	22
	2.1. Introduction	22
	2.2. Chemokine Structures	24
	2.3. Chemokine-Receptor Interactions	33
	2.4. Chemokine-Glycosaminoglycan Interactions	36
	2.5. Future Directions	38
	References	38
	3 Chemokine Receptors: A Structural Overview (Gerard J. Graham and Robert J. Nibbs)	44
	3.1. Background of the Chemokine Receptors	44
	3.2. Ligand Binding by Chemokine Receptors	47
	3.3. Primary Structural Determinants of Chemokine Receptor Function	50
	3.4. Signaling by Chemokine Receptors	56
	3.5. Chemokine Receptor Dimerization	57
	3.6. Determination of the Three-Dimensional Structure of the Chemokine Receptors	59
	3.7. Conclusions	61
	References	61
	4 Chemokine Signaling in T- Lymphocyte Migration: The Role of Phosphoinositide 3- kinase (Laura Smith, Adam Webb, and Stephen G. Ward)	68
	4.1. Introduction	69
	4.2. The Role of Phosphoinositide 3-kinase(s) in T- Lymphocyte Migration	69
	4.3. What Is the Signi.cance of Rho GTPases in T- Lymphocyte Migration?	75
	4.4. Activation of Protein Tyrosine Kinases by Chemokines: Relevance to T- Lymphocyte Migration	76
	4.5. Evidence of a Role for Protein Kinase C Activation in T- Lymphocyte Migration	77
	4.6. Importance of Tailoring the Migratory Response	78
	4.7. Conclusions	80
	References	80
	5 Chemokine Receptors and Neutrophil Trafficking (Teizo Yoshimura)	84
	5.1. Introduction	84
	5.2. Role for CXCR1 and CXCR2 in Tissue In.ltration of Neutrophils	85
	5.3. Role for CC Chemokine Receptors in the Traf.cking of Neutrophils	88
	5.4. Role for CXCR4 in Neutrophil Retention and Mobilization	91
	5.5. Conclusions	93
	Acknowledgments	94
	References	94
	6 Chemokine Receptors and Dendritic Cell Trafficking (Hiroyuki Yoneyama, Kenjiro Matsuno, and Kouji Matsushima)	100
	6.1. The Concept of Migration-Dependent Dendritic Cell Activation	100
	6.2. Two Subsets of Naïve Dendritic Cells with Distinct Migration and Functional Potentials	102
	6.3. The Impact of Migration of Dendritic Cells on Their Effector Functions	105
	6.4. Regulation by Chemokines of Dendritic Cell Migration– Dependent Immunity	107
	6.5. Induction of Primed pDCs by Trans-HEV Migration	108
	6.6. Concerted Recruitment of mDCs and pDCs: The Role of Chemokines	109
	References	111
	7 Chemokine Receptors and Lymphocyte Trafficking (Michael N. Hedrick and Joshua M. Farber)	113
	7.1. Chemokines and Primary Lymphoid Organs	114
	7.2. Chemokines and Secondary Lymphoid Organs	116
	7.3. Chemokines and Lymphocytes in the Periphery	117
	7.4. Conclusions	123
	References	123
	8 Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis (Chang H. Kim)	131
	8.1. Introduction	132
	8.2. Regulation of Survival and Proliferation of Hematopoietic Stem and Progenitor Cells by Chemokines	133
	8.3. Regulation of the Homing and Mobilization of Hematopoietic Stem and Progenitor Cells	136
	8.4. Development of Hematopoietic Cell Lineage–Specific Migration Program	139
	8.5. Conclusions	142
	Acknowledgments	143
	References	143
	9 Chemokines in Transplantation Biology (Peter Jon Nelson, Stephan Segerer, and Detlef Schlondorff)	151
	9.1. Introduction	151
	9.2. The Immunobiology of Vascularized Allografts	152
	9.3. Chemokines and the Directed Recruitment of Leukocytes into Allografts	154
	9.4. Chemokine Polymorphisms as Predisposing or Prognostic Factors	161
	9.5. Conclusions	161
	References	161
	10 The Chemokine System and Arthritis (Marlon P. Quinones, Fabio Jimenez, Carlos A. Estrada, Hernan G. Martiniez, and Seema S. Ahuja)	167
	10.1. Introduction	167
	10.2. Role of Chemokines During the Different Phases of Rheumatoid Arthritis	168
	10.3. Effects of Chemokine System Inactivation in Arthritis	182
	10.4. Signaling Cascades Underlying the Effects of Chemokines in Arthritis	191
	10.5. Some Unsolved Issues Regarding Chemokines in Arthritis	191
	10.6. Effects of Chemokines in Rheumatoid Arthritis Beyond Cell Recruitment	194
	10.7. Conclusions	196
	Acknowledgments	196
	References	196
	11 Chemokine Receptors in Atherosclerosis (Maya R. Jerath, Mildred Kwan, Peng Liu, and Dhavalkumar D. Patel)	211
	11.1. Introduction	211
	11.2. Animal Models	218
	11.3. Chemokines and Receptors	219
	11.4. Therapeutic Implications	230
	11.5. Conclusions	233
	References	234
	12 Chemokine Receptors in Allergic Lung Disease (Dennis M. Lindell and Nicholas W. Lukacs)	246
	12.1. Introduction	247
	12.2. Th1 versus Th2 Chemokine Receptor Pro.les	248
	12.3. CCR3	253
	12.4. CCR1	255
	12.5. CCR2	255
	12.6. CXCR4	257
	12.7. CXCR1/CXCR2	257
	12.8. CX3CR1/CX3CL1	258
	12.9. Conclusions	258
	Acknowledgments	260
	References	260
	13 Chemokine Receptors and HIV/AIDS (Tzanko S. Stantchev an