| Cover | 1 |
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| Contents | 6 |
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| Preface | 10 |
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| Introduction | 12 |
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| Advances in the Planning and Delivery of Radiotherapy: New Expectations, New Standards of Care | 12 |
| Abstract | 12 |
| The Expansion of Radiation Oncology Technologies | 12 |
| Target Volume Specification and Treatment: Issues of Accuracy | 16 |
| Intensity-Modulated Radiation Therapy/Image-Guided Radiation Therapy Planning and Delivery Technologies: Current Challenges | 19 |
| Proton and Heavy Ion Radiation Therapy | 30 |
| Radiation Dose and Second Cancers | 32 |
| Radiation Oncology Informatics | 34 |
| Conclusions | 35 |
| References | 37 |
| General Concepts and Methods | 40 |
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| Advanced Technologies in the Radiotherapy Clinic: System Fundamentals | 40 |
| Abstract | 40 |
| A Typical Intensity-Modulated Radiotherapy Treatment Planning System | 41 |
| Target Localization and Image Guidance | 43 |
| Image Registration | 52 |
| Adaptive Radiotherapy | 61 |
| References | 66 |
| Economic Perspectives | 71 |
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| Controversies in the Adoption of New Healthcare Technologies | 71 |
| Abstract | 71 |
| Health Technology Assessment | 71 |
| Payment Policy Development: Past and Present Realities, and Future Uncertainties | 77 |
| Cost-Effectiveness Methodologies, Implications in an Era of Value-Based Purchasing | 83 |
| Conclusions | 88 |
| References | 89 |
| IMRT: Advances in Treatment Design and Delivery | 91 |
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| Clinical Implementation of Intensity-Modulated Arc Therapy | 91 |
| Abstract | 91 |
| Intensity-Modulated Arc Therapy: Basic Concepts | 92 |
| Why Rotational Intensity-Modulated Radiation Therapy? | 93 |
| Commercial Intensity-Modulated Arc Therapy Solutions | 96 |
| Clinical Implementation of Intensity-Modulated Arc Therapy | 99 |
| References | 108 |
| IGRT: Advances in Targeting Therapy | 110 |
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| 4D Imaging and 4D Radiation Therapy: A New Era of Therapy Design and Delivery | 110 |
| Abstract | 110 |
| Impact of Breathing Motion on Images | 111 |
| Impact of Breathing Motion during Treatments | 117 |
| Methods to Account for Breathing Motion | 120 |
| Future Directions | 126 |
| Acknowledgements | 127 |
| References | 127 |
| Locating and Targeting Moving Tumors with Radiation Beams | 129 |
| Abstract | 129 |
| How Do We Locate the Moving Target? | 133 |
| How Do We Hit a Moving Target? | 137 |
| How Do We Create Integrated Systems to Locate and Hit Moving Targets? | 139 |
| Conclusions | 139 |
| References | 140 |
| Integrating IMRT and IGRT into Treatment Delivery | 143 |
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| Technologies of Image Guidance and the Development of Advanced Linear Accelerator Systems for Radiotherapy | 143 |
| Abstract | 143 |
| Technologies to Meet the Goals of Image-Guided Radiation Therapy | 146 |
| Image Guidance Systems and Procedures | 148 |
| Cone-Beam CT for Linac-Based Image-Guided Radiation Therapy | 154 |
| Image Guidance: Meeting Future Needs | 165 |
| Conclusions | 169 |
| References | 169 |
| HelicalTomotherapy: Image-Guided and Adaptive Radiotherapy | 176 |
| Abstract | 176 |
| System Overview | 177 |
| Clinical Applications of Helical Tomotherapy | 178 |
| Daily Megavoltage-Based CT Imaging | 179 |
| Dose Evaluation and Adaptive Radiotherapy | 186 |
| Conclusions | 190 |
| References | 190 |
| The CyberKnife in Clinical Use: Current Roles, Future Expectations | 192 |
| Abstract | 192 |
| The CyberKnife System | 192 |
| Advances in CyberKnife Treatment Planning and Dose Delivery | 194 |
| Current Clinical Applications of CyberKnife | 199 |
| The Future of CyberKnife | 202 |
| References | 203 |
| Image Guidance and the New Practice of Radiotherapy: What to Know and Use from a Decade of Investigation | 207 |
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| Abstract | 207 |
| The Rationale for Image-Guided Radiation Therapy: Perspectives on the Current Practice of Radiotherapy | 207 |
| Challenges in Image-Guided Radiation Therapy | 213 |
| Clinical Applications of Image-Guided Radiation Therapy | 217 |
| Adaptive Radiotherapy | 223 |
| Conclusions | 225 |
| References | 226 |
| Head and Neck Cancers | 228 |
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| Intensity-Modulated and Image-Guided Radiation Therapy for Head and Neck Cancers | 228 |
| Abstract | 228 |
| Intensity-Modulated Radiation Therapy/Image-Guided Radiation Therapy Planning for Head and Neck Cancers | 229 |
| Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinomas | 245 |
| Intensity-Modulated Radiation Therapy for Oropharyngeal Carcinomas | 256 |
| Conclusions | 260 |
| Guidelines for Clinical Practice | 261 |
| References | 262 |
| Delineating Neck Targets for Intensity-Modulated Radiation Therapy of Head and Neck Cancer | 266 |
| Abstract | 266 |
| Tumor and Target Volumes in the Neck | 267 |
| Target Doses and Techniques | 275 |
| Case Studies | 278 |
| Guidelines for Clinical Practice | 278 |
| References | 280 |
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