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Clinical Update on Inflammatory Disorders of the Gastrointestinal Tract Frontiers of Gastrointestinal Research, Vol. 26

:	J. Mayerle, H. Tilg
:	Clinical Update on Inflammatory Disorders of the Gastrointestinal Tract Frontiers of Gastrointestinal Research, Vol. 26
:	Karger
:	9783805592956
:	1
:	CHF 196.10
:

:	Klinische Fächer
:	English

:	226
:	DRM
:	PC/MAC/eReader/Tablet
:	PDF/ePUB

Digestive-diseas -associated mortality accounts for a major part of all deaths in Western societies and inflammatory diseases such as GI infections, viral hepatitis, GERD or cancers due to chronic inflammation have a tangible economic and social impact. What further aggravates the situation is the fact that complex immunological disorders have surfaced where anti-infective treatments are not effective. Fortunately, due to breakthroughs in basic research that are being successfully translated into clinical practice, new treatment strategies are constantly evolving. In addition to the development of new therapeutic measures, however, it is also mandatory to review and periodically refine established treatment regimens to reflect current knowledge and ensure up-to-date medical care.

	Cover	1
	Contents	6
	Preface	8
	Non-Alcoholic Fatty Liver Disease	10
	Abstract	10
	Nomenclature	10
	Epidemiology and Natural History	11
	Pathogenesis	13
	Clinical Features and Investigation	15
	Therapy	16
	Conclusions	21
	References	21
	Fibrosis in the GI Tract: Pathophysiology, Diagnosis and Treatment Options	24
	Abstract	24
	Cellular and Molecular Mechanisms of Fibrosis in the GI Tract	24
	Liver Fibrosis	32
	Pancreatic Fibrosis	33
	Intestinal Fibrosis	34
	Clinical Evaluation of Fibrosis Progression/Regression	34
	Potential Anti-Fibrogenic Strategies	35
	References	36
	Chronic Hepatitis B: Pathophysiology, Diagnosis and Treatment Options	41
	Abstract	41
	Phases of Hepatitis B Infection	43
	Role of Viral Load	43
	Immunopathogenesis	44
	Treatment Options in Chronic Hepatitis B	46
	Summary	48
	References	49
	Chronic Hepatitis C: Pathophysiology, Diagnosis and Treatment Options	51
	Abstract	51
	Viral Cycle	51
	Interferon Signalling and HCV Infection	54
	Innate and Adaptive Immunity to HCV Infection	56
	Progression of Fibrosis in Hepatitis C	58
	Predictive Factors of Response to Treatment	59
	Genome-Wide Association Studies Identified SNPs in the IL28B Region Associated with Response to Treatment	60
	Molecular Signatures of Response in Liver	60
	Standard of Care: Combined PEG-IFN Plus Ribavirin	62
	Specifically Targeted Antiviral Therapy for HCV	62
	Conclusion	64
	Acknowledgment	64
	References	65
	Clinical Update on Inflammatory Disorders of the GI Tract: Liver Transplantation	68
	Abstract	68
	Primary Sclerosing Cholangitis	69
	Autoimmune Hepatitis	74
	PSC and AIH: Similarities and Differences	76
	References	78
	Hepatocellular Carcinoma	81
	Abstract	81
	Incidence and Epidemiology	81
	Screening and Surveillance	82
	Diagnosis and Staging	82
	Treatment	83
	Surgical Interventions for Advanced HCC	84
	Locoablative Therapies with Curative Intent	86
	Established palliative Therapeutic Intervention for Advanced HCC	87
	Transarterial Chemoembolization	87
	Drug Treatment for Advanced HCC	88
	Non-Established and Experimental Treatment Options	89
	References	89
	Coeliac Disease	92
	Abstract	92
	Coeliac Disease, Epidemiology and Symptoms	92
	Pathogenesis of Coeliac Disease	94
	Genetic and Other Risk Factors	98
	Oral Tolerance to Gluten	98
	Intestinal Gluten Transport	98
	Novel Therapies for Coeliac Disease	99
	Conclusions	99
	Acknowledgments	101
	References	101
	Anti-TNF Therapy in Inflammatory BowelDiseases	104
	Abstract	104
	Methods	105
	Results	105
	Conclusion	113
	References	114
	Role of Epithelial Cells in Inflammatory Bowel Disease	117
	Abstract	117
	Endoplasmic Reticulum Stress	118
	Autophagy	120
	NOD2	121
	Organic Cation Transporters	122
	NF?B	123
	Conclusion	124
	References	124
	GI Immune Response in Functional GI Disorders	127
	Abstract	127
	Introduction	127
	Presence of Inflammation	128
	Summary	132
	References	132
	Probiotics in GI Diseases	135
	Abstract	135
	Probiotics	135
	Inflammatory Bowel Disease	136
	H. pylori Infection	139
	Irritable Bowel Syndrome	140
	Diverticular Disease	141
	Conclusions	141
	References	142
	Microscopic Colitis	144
	Abstract	144