: H.-P. Hammes, M. Porta
: Experimental Approaches to Diabetic Retinopathy Frontiers in Diabetes, Vol. 20
: Karger
: 9783805592765
: 1
: CHF 202.90
:
: Klinische Fächer
: English
: 242
: DRM
: PC/MAC/eReader/Tablet
: PDF/ePUB
This volume sets the stage for clinical experts working with diabetic patients as well as for researchers by describing the clinical presentations of retinopathy and their anatomical and functional correlates. It reviews currently available experimental models in animals. The impact of retinal pericytes, neuroglia and, specifically, Müller cells are discussed in detail. The volume addresses a variety of current scientific discussions about mechanisms of damage such as growth factors and the VEGF/PEDF balance in the diabetic eye, the ocular renin-angiotensin system, and leukocyte interactions with the microvasculature among others. Stem and progenitor cells in the retina are discussed as potential directions for future investigation. The final chapters return to emerging clinical aspects, including current approaches to retinopathy as a predictor of cardiovascular risk and how knowledge can be translated from bench to bedside.
Cover1
Contents6
Preface8
Clinical Presentations and Pathological Correlates of Retinopathy10
Abstract10
Morphological Lesions11
Pattern of Distribution of Retinopathy Lesions23
Visual Impairment in Diabetic Retinopathy25
Conclusions25
References26
Retinal Vascular Permeability in Health and Disease29
Abstract29
Physiology of the Retinal Vascular Network30
Physiology of the Blood-Retinal Barrier30
Molecular Biology of the Blood-Retinal Barrier31
Pathophysiology of the Blood-Retinal Barrier Breakdown33
Macular Edema35
Assays for Studying the Permeability of the Blood-Retinal Barrier35
Retinal Diseases Where the Blood-Retinal Barrier Is Impaired37
Blood-Retinal Barrier Breakdown and Drug Delivery41
Medical and Surgical Treatments for Blood-Retinal Barrier Breakdown41
Conclusions44
References44
In vivo Models of Diabetic Retinopathy51
Abstract51
Early Stage of Diabetic Retinopathy, Histopathology52
Animal Models of Diabetic Retinopathy54
Neovascularization63
Conclusions63
References64
Pericyte Loss in the Diabetic Retina70<