| Cover | 1 |
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| Contents | 6 |
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| Foreword | 7 |
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| Preface | 9 |
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| The Migrating Cell | 10 |
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| Abstract | 10 |
| Acknowledgement | 14 |
| References | 14 |
| Stem Cell Migration in Health and Disease | 16 |
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| Abstract | 16 |
| HSC/HSPC Mobilization | 19 |
| HSC/HSPC Homing | 21 |
| The SDF-1a/CXCR4 Axis | 23 |
| Modulation of the SDF-1a-Induced Migration of HSPCs | 26 |
| Cancer Stem Cell Migration | 27 |
| Conclusion | 30 |
| Acknowledgements | 31 |
| References | 31 |
| Leukocyte Motility and Human Disease | 37 |
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| Abstract | 37 |
| Basic Steps of Cell Movement | 37 |
| External Factors That Regulate Cell Migration | 38 |
| Cell Signaling during Neutrophil-Directed Migration | 38 |
| Neutrophil Motility in Disease | 43 |
| Neutrophil Motility in Chronic Inflammatory Disease | 44 |
| Conclusion | 45 |
| References | 46 |
| Coordination of Leukocyte Polarity and Migration | 49 |
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| Abstract | 49 |
| Leukocyte Polarization | 49 |
| Sensing Chemotactic Gradients | 52 |
| Establishment of Two Poles: Front-Back Coordination | 54 |
| Microtubule Connection: The Lost Link? | 56 |
| Segregated Signalling Domains in Polarized Lymphocytes | 58 |
| Concluding Remarks | 60 |
| References | 60 |
| Positioning Phosphoinositide 3-Kinase in Chemokine and Antigen-Dependent T-Lymphocyte Navigation Mechanisms | 63 |
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| Abstract | 63 |
| Class 1 PI3Ks: An Overview | 64 |
| A Role for PI3K in Cell Migration: The Story So Far | 65 |
| Evidence for PI3K-Dependent and -Independent T-Lymphocyte Directional Migration | 66 |
| Role of PI3K in T-Lymphocyte Homing and Migration in vivo: Lessons from Gene-Targeted from Mice | 67 |
| Role of PI3K in Interstitial T-Lymphocyte Motility | 68 |
| Antigen Recognition by the TCR and Costimulatory Receptors Influence T-Cell Trafficking | 68 |
| PI3K Influences Effector T-Cell Migration at Transcriptional and Post-Translational Levels | 70 |
| Conclusions | 70 |
| Acknowledgement | 72 |
| References | 72 |
| Migration of Functionally Specialized T-Helper Cells: TFH Cells, Th17 Cells and FoxP3+ T Cells | 76 |
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| Abstract | 76 |
| Migration and Trafficking Receptors of T Cells | 77 |
| Generation of the Functionally Specialized T-Helper Cell Subsets | 78 |
| Migration and Function of TFH Cells | 79 |
| Migration and Function of Th17 Cells | 82 |
| Migration and Function of FoxP3+ Cells | 84 |
| Concluding Remarks | 85 |
| References | 86 |
| ADAMs and Ectodomain Proteolytic Shedding in Leukocyte and Tumour Cell Migration | 92 |
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| Abstract | 92 |
| Leukocyte Trafficking | 93 |
| ADAMs and Ectodomain Shedding of Leukocyte Receptors | 95 |
| CD44 Shedding and T-Cell Recruitment in Autoimmune Lesions | 100 |
| ADAMs and Ectodomain Shedding of Endothelial Receptors | 100 |
| Crossing the Basement Membrane and Interstitial Migration | 101 |
| ADAMs and Ectodomain Shedding in Tumour Cell Extravasation | 102 |
| How, Where and When Are ADAMs Activated | 102 |
| Regulation of ADAM10 and 17 Proteolytic Activity | 103 |
| Regulation of ADAM15 Function by Interacting Kinases | 104 |
| Conclusions and Future Prospects | 105 |
| References | 106 |
| Guided Tour of Cell Migration: Signals and Pathways | 111 |
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| Abstract | 111 |
| Induction of Migratory Activity by Extracellular Signal Substances | 112 |
| Pathways Leading to Cell Migration (Cytokines and Neurotransmitters) | 118 |
| Conclusion | 123 |
| Acknowledgement | 123 |
| References | 123 |
| Regulation of the E-Cadherin Adhesion Complex in Tumor Cell Migration and Invasion | 129 |
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| Abstract | 129 |
| E-Cadherin-Mediated Adherens Junctions | 130 |
| Regulation of E-Cadherin Gene Expression | 131 |
| Regulation of the E-Cadherin Adhesion Complex by ß-Catenin | 134 |
| Regulation of Cell-Cell Adhesion by the Cellular Microenvironment | 136 |
| Regulation of Cell-Cell Adhesion by p120ctn and GTPases | 138 |
| References | 140 |
| The Cytoskeletal Connection: Understanding Adaptor Proteins | 145 |
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| Abstract | 145 |
| The Cell Adhesion Complex: A Simplistic View | 145 |
| Proteins: Biochemical Characteristics and Molecular Architecture | 147 |
| Cell Adhesion Complex: Protein Properties in the Cellular Context | 150 |
| Cell Migration: Regulation of Adaptor Proteins during Contact Turnover | 156 |
| Organism: Specific Tasks in Tissues and Organs | 164 |
| Concluding Remarks | 165 |
| Acknowledgements | 166 |
| References | 166 |
| Locomotor Force Generation by Myosins | 172 |
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| Abstract | 172 |
| The Myosin Superfamily | 172 |
| Myosin I | 175 |
| Myosin II | 175 |
| Myosin V | 176 |
| Myosin VI | 178 |
| Myosin VII | 178 |
| Myosin X | 178 |
| Concluding Remarks | 179 |
| Acknowledgement | 179 |
| References | 179 |
| Author Index | 182 |
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| Subject Index | 183 |
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